4-Mercaptophenylacetic acid
ALDRICH/653152 - 97%
Synonym: (4-
CAS Number: 39161-84-7
Empirical Formula (Hill Notation): C8H8O2S
Molecular Weight: 168.21
MDL Number: MFCD00797617
Linear Formula: HSC6H4CH2CO2H
Product Type: Chemical
| assay | 97% |
| form | solid |
| InChI | 1S/C8H8O2S/c9-8(10)5-6-1- |
| InChI key | ORXSLDYRYTVAPC-UHFFFAOYSA |
| mp | 105-109 °C (lit.) |
| SMILES string | OC(=O)Cc1ccc(S)cc1 |
| storage temp. | 2-8°C |
| Application: | 4-Mercaptophenylacetic acid has been used in the preparation of small ubiquitin-like modifier peptides from bis(2-sulfanylethyl)amido peptide via sequential native chemical ligation. It can be used: • On-resin preparation of peptide-α thiophenylesters which are used in a chemical ligation process for the chemical synthesis of peptides. • In one pot deprotection of (acetamido-methyl)cystein • Palladium facilitated deprotection of N-terminal cysteine through native chemical ligation method for the preparation of synthetically challenging proteins. |
| General description: | 4-Mercaptophenylacetic acid (MPAA), a thiol additive, is widely used in Native Chemical Ligation (NCL) reactions for selective and efficient ligation of peptide fragments. |
| Packaging: | 1, 5 g in glass bottle |
| Symbol |   GHS05,GHS07 |
| Signal word | Danger |
| Hazard statements | H315 - H318 - H335 |
| Precautionary statements | P280 - P302 + P352 - P305 + P351 + P338 + P310 |
| Hazard Codes | Xi |
| Risk Statements | 37/38-41 |
| Safety Statements | 26-36/37/39 |
| RIDADR | UN 3335 |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 97% |
| mp | 105-109 °C (lit.) |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352100 |