2,4-Dichloro-5-fluoropyrimidine

ALDRICH/653233 - 97%

CAS Number: 2927-71-1
Empirical Formula (Hill Notation): C₄HCl₂FN₂
Molecular Weight: 166.97
MDL Number: MFCD00233551
Linear Formula: C₄HCl₂FN₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-653233-1G	1 g	$58.70 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 653233-1G

Properties
Descriptions
Safety Info.
Basic Data

assay	97%
form	solid
functional group	chloro
	fluoro
InChI	1S/C4HCl2FN2/c5-3-2(7)1-8-4(6)9-3/h1H
InChI key	WHPFEQUEHBULBW-UHFFFAOYSA-N
mp	37-41 °C (lit.)
Quality Level	100
SMILES string	Fc1cnc(Cl)nc1Cl

Application:

2,4-Dichloro-5-fluoropyrimidine can be used as a starting material to synthesize:
• 5-fluoropyrimidine-2-carboxamides and 5-fluoropyrimidine-4-carboxamides as potential kinase inhibitors.
• A series of 2,4-diamino-5-fluoropyrimidine derivatives as potential protein kinase Cθ inhibitors.
• 2,4-Bisanilinopyrimidine derivatives as potential aurora kinases inhibitors.
• 5-fluoro-N,N-bis(4-methoxyphenyl)-2,4-pyrimidinediamine by reacting with p-methoxy aniline in the presence of DIPEA.
• 2-chloro-5-fluoro-4-(4-fluorophenyl)pyrimidine by Suzuki coupling reaction in the presence of (4-fluorophenyl)boronic acid triphenylphosphine, and palladium(II) acetate catalyst.
• 5-fluoro-2-(piperidin-4-yloxy)pyrimidin-4-amine, a scaffold, which is used in the preparation of potent deoxycytidine kinase inhibitors.

Packaging:

1 g in glass bottle

Symbol	GHS05,GHS07
Signal word	Danger
Hazard statements	H302 - H314
Precautionary statements	P260 - P280 - P301 + P312 + P330 - P301 + P330 + P331 - P303 + P361 + P353 - P305 + P351 + P338
Hazard Codes	C
Risk Statements	22-34
Safety Statements	26-36/37/39-45
RIDADR	UN 3261 8 / PGIII
WGK Germany	WGK 3
Flash Point(F)	222.8 °F - closed cup
Flash Point(C)	106 °C - closed cup

Purity	97%
mp	37-41 °C (lit.)
UNSPSC	12352100

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