(S)-4-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline

ALDRICH/688495 - 97%

Synonym: (4S)-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-4,5-dihydrooxazole

CAS Number: 148461-16-9
Empirical Formula (Hill Notation): C₂₅H₂₆NOP
Molecular Weight: 387.45
MDL Number: MFCD09998277
Linear Formula: C₂₅H₂₆NOP
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-688495-500MG	500 mg	$427.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	97%
form	solid
InChI	1S/C25H26NOP/c1-25(2,3)23-18-27-24(26-23)21-16-10-11-17-22(21)28(19-12-6-4-7-13-19)20-14-8-5-9-15-20/h4-17,23H,18H2,1-3H3/t23-/m1/s1
InChI key	DMOLTNKQLUAXPI-HSZRJFAPSA-N
mp	111-116 °C
optical activity	[α]22/D -57.0°, c = 1 in chloroform
SMILES string	CC(C)(C)[C@@H]1N=C(C2=CC=CC=C2P(C3=CC=CC=C3)C4=CC=CC=C4)OC1
storage temp.	−20°C

Application:	(S)-4-tert-Butyl-2-[2-(diphenylphosphino)phenyl]-2-oxazoline can be used as a ligand for enantioselective Heck reaction without any C=C double bond migration byproduct. It can also be used in a rhodium(I)-catalyzed enantioselective desymmetrization reaction of meso-3,5-dimethyl glutaric anhydride, to form substituted syn-deoxypolypropionate fragments in a single transformation.
General description:	The product is a phosphinooxazoline (PHOX) ligand introduced by Pfaltz and coworkers. These non-symmetrical modular P,N-ligands are particularly useful in cases where double bond migration leads to undesired products or mixtures of isomers.
Packaging:	100 mg in clear glass bottle
Packaging:	500 mg in amber glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	97%
mp	111-116 °C
Storage Temp.	−20°C
UNSPSC	12352005

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