(S)-SIPHOS-PE

ALDRICH/700762 - 97%

Synonym: (11aS)-(−)-10,11,12,13-Tetrahydrodiindeno[7,1-de:1′, 7′-fg][1,3,2]dioxaphosphocin-5-bis[(R)-1-phenylethyl]amine; N-Di[(R)-1-phenylethyl]-[(S)-1,1′-spirobiindane-7,7′-diyl]-phosphoramidite

CAS Number: 500997-70-6
Empirical Formula (Hill Notation): C₃₃H₃₂NO₂P
Molecular Weight: 505.59
MDL Number: MFCD08459342
Linear Formula: C₃₃H₃₂NO₂P
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-700762-250MG	250 mg	$669.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	97%
form	powder
functional group	amine
	phenyl
InChI	1S/C33H32NO2P/c1-23(25-11-5-3-6-12-25)34(24(2)26-13-7-4-8-14-26)37-35-29-17-9-15-27-19-21-33(31(27)29)22-20-28-16-10-18-30(36-37)32(28)33/h3-18,23-24H,19-22H2,1-2H3/t23-,24-,33?/m1/s1
InChI key	ZXLQLIDJAURBDD-HRPAVAKOSA-N
mp	120-125 °C
optical activity	[α]22/D −65.0°, c = 1 in chloroform
Quality Level	100
SMILES string	C[C@@H](N([C@H](C)c1ccccc1)P2Oc3cccc4CCC5(CCc6cccc(O2)c56)c34)c7ccccc7
storage temp.	−20°C

Application:

(S)-SIPHOS-PE is a chiral spiro phosphoramidate ligand that can be used to synthesize:
• Spiroindolenines by Pd-catalyzed intramolecular dearomative arylation of haloaryl-3-substituted indoles.
• Enantioselective conjugate addition compound by Cu-catalyzed 1,4-addition of diethylzinc (Et₂Zn) to cyclic enones.
• Octaketide natural products via rhodium-phosphoramidite catalyzed alkene hydroacylation.

Packaging:

50, 250 mg in amber glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P261 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36/37
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	97%
mp	120-125 °C
Storage Temp.	−20°C
UNSPSC	12352005

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