DCA Deblock (0.36M dichloroacetic acid in toluene)
ALDRICH/707066
Synonym: DCA Deblock; DEBLOCK (0.36M dichloroacetic acid in toluene)
CAS Number: 79-43-6
Empirical Formula (Hill Notation): C2H2Cl2O2
Molecular Weight: 128.94
MDL Number: MFCD00004223
Linear Formula: C2H2Cl2O2
Product Type: Chemical
| bp | 110-111 °C |
| concentration | ≤100 ppm in H2O |
| density | 0.884 g/mL at 25 °C |
| form | liquid |
| InChI | 1S/C2H2Cl2O2/c3-1(4)2(5)6 |
| InChI key | JXTHNDFMNIQAHM-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | OC(=O)C(Cl)Cl |
| Application: | DCA Deblock (0.36M dichloroacetic acid in toluene) is suitable for the removal of 4,4Adimethoxytrityl (DMTr) protecting groups for the synthesis of antisense oligonucleotides in high yield and purity. |
| General description: | Deblock solution, containing dichloroacetic acid (DCA) in dichloromethane or Toluene, removes the dimethoxytrityl (DMT) protecting the group from the 5′ hydroxyl moiety of nucleotides already incorporated into the growing nucleic acid, prior to the addition of the next phosphoramidite. Removal of the DMT allows the unprotected 5′ hydroxyl moiety to react with a new phosphoramidite in a subsequent extension reaction. |
| Packaging: | 200 L in Pure-Pac™ 1 |
| Packaging: | 4×4 L in glass bottle |
| Packaging: | 50 L in Pure-Pac™ 2 |
| Symbol |      GHS02,GHS05,GHS07,GHS08,GHS09 |
| Signal word | Danger |
| Hazard statements | H225 - H304 - H315 - H318 - H336 - H351 - H360FD - H373 - H410 |
| Precautionary statements | P210 - P273 - P280 - P301 + P310 - P305 + P351 + P338 - P331 |
| Hazard Codes | F,Xn,N |
| Risk Statements | 63-11-36/38-48/20-50-65-67 |
| Safety Statements | 16-26-36/37-61-62 |
| RIDADR | UN1993 - class 3 - PG 2 - EHS - VP <= 110kPa - Flammable liquids |
| WGK Germany | WGK 2 |
| Flash Point(F) | 41.0 °F |
| Flash Point(C) | 5 °C |
| bp | 110-111 °C |
| Density | 0.884 g/mL at 25 °C |
| UNSPSC | 12352106 |