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1-Hydroxybenzotriazole hydrate

ALDRICH/711489 - wetted with not less than 20 wt. % water, 97% dry basis

Synonym: HOBt Hydrate

CAS Number: 123333-53-9
Empirical Formula (Hill Notation): C6H5N3O · xH2O
Molecular Weight: 135.12 (anhydrous basis)
EC Number: 219-989-7
MDL Number: MFCD00065690
Linear Formula: C6H5N3O · xH2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-711489-50G 50 g
 $146.00
1/EA		 Add To Favorites
45-711489-250G 250 g
 $494.00
1/EA		 Add To Favorites
45-711489-1KG 1 kg
 $1530.00
1/EA		 Add To Favorites

 

assay 97% dry basis
composition Water content, ~20%
form powder
InChI 1S/C6H5N3O.H2O/c10-9-6-4-2-1-3-5(6)7-8-9;/h1-4,10H;1H2
InChI key PJUPKRYGDFTMTM-UHFFFAOYSA-N
mp 155-158 °C (lit.)
quality wetted with not less than 20 wt. % water
Quality Level 200 
reaction suitability reaction type: Addition Reactions
SMILES string [H]O[H].On1nnc2ccccc12
solubility DMF: 0.1 g/mL, clear
Application: 1-Hydroxybenzotriazole hydrate is used as an additive:
• In the oligonucleotide couplings.
• In the preparation of poly(ethylene glycol)methyl ether-grafted CTS (mPEG-g-CTS).
1-Hydroxybenzotriazole hydrate can also be used:• In the solid phase peptide synthesis on TCNEO(tetracyanoethylene oxide)-modified graphite.
General description: 1-Hydroxybenzotriazolehydrate (HOBt hydrate) is a hydrated form of HOBt. HOBt is a nucleophilic additive commonly used in synthetic chemistry. It is widely employed as acatalyst or stoichiometric additive to accelerate nucleophilic acyl substitution reactions, specifically amidations. Additionally, it is also used in the synthesis of peptides and nucleotides.
Packaging: 50, 250 g in poly bottle
Purity 97% dry basis
mp 155-158 °C (lit.)
UNSPSC 12352000

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