Josiphos SL-J009-1 Pd G3

ALDRICH/747130

Synonym: Josiphos SL-J009-1-G3-palladacycle; {(R)-1-[(Sp)-2-(Dicyclohexylphosphino)ferrocenyl]ethyldi-tert-butylphosphine}[2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate

CAS Number: 1702311-34-9
Empirical Formula (Hill Notation): C₄₅H₆₅FeNO₃P₂PdS
Molecular Weight: 924.28
MDL Number: MFCD27978424
Linear Formula: C₄₅H₆₅FeNO₃P₂PdS
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-747130-100MG	100 mg	$0.00 1/EA CALL FOR PRICE	Add To Favorites
45-747130-250MG	250 mg	$292.00 1/EA	Add To Favorites
45-747130-1G	1 g	$1010.00 1/EA	Add To Favorites
45-747130-5G	5 g	$4410.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

feature	generation 3
form	solid
functional group	phosphine
InChI	1S/C27H47P2.C12H10N.C5H5.CH4O3S.Fe.Pd/c1-21(29(26(2,3)4)27(5,6)7)24-19-14-20-25(24)28(22-15-10-8-11-16-22)23-17-12-9-13-18-23;13-12-9-5-4-8-11(12)10-6-2-1-3-7-10;1-2-4-5-3-1;1-5(2,3)4;;/h14,19-23H,8-13,15-18H2,1-7H3;1-6,8-9H,13H2;1-5H;1H3,(H,2,3,4);;/q;;;;;+1/p-1/t21-;;;;;/m1...../s1
InChI key	GJFJVCUFUWXFEB-RPDSBUJNSA-M
mp	180-186 °C
Quality Level	100
reaction suitability	core: palladium
	reaction type: Buchwald-Hartwig Cross Coupling Reaction
	reaction type: Cross Couplings
	reaction type: Heck Reaction
	reaction type: Hiyama Coupling
	reaction type: Negishi Coupling
	reaction type: Sonogashira Coupling
	reaction type: Stille Coupling
	reaction type: Suzuki-Miyaura Coupling
	reagent type: catalyst
SMILES string	NC1=C(C=CC=C1)C2=C([Pd]OS(C)(=O)=O)C=CC=C2.C[C@@H](P(C(C)(C)C)C(C)(C)C)[C]3[C](P(C4CCCCC4)C5CCCCC5)[C][C][C]3.[C]6[C][C][C][C]6.[Fe]

Application:	Total Syntheses of N-Paspaline and N-Emindole PB: Discusses the use of various catalysts including RuPhos and Josiphos ligands for synthesizing complex molecular structures (Radical-Polar Crossover Cyclizations, 2020 ). Unprotected Indazoles Are Resilient to Ring-Opening Isomerization: A Case Study on Catalytic C-S Couplings in the Presence of Strong Base: Utilizes Josiphos SL-J009-1 Pd-G3 for catalytic C-S coupling reactions under strong base conditions (The Journal of Organic Chemistry, 2017 ). Synthesis and characterization of an isopropylBippyPhos precatalyst: Compares various phosphine ligands including XPhos and Josiphos for catalytic activity in organic syntheses (Tetrahedron, 2022 ). Novel quorum sensing inhibitors targeting PqsR: Mentions the experimental use of Josiphos ligands in the synthesis of potential pharmaceutical compounds (2020, University of Saarland ).
General description:	Josiphos SL-J009-1 Pd G3 (Josiphos SL-J009-1-G3-palladacycle) is a modified G3 precatalyst (G3′). It has been synthesized by Buchwald and coworkers from second generation (G2) precatalyst by methylation of the amino group present on biphenyl backbone. It is a useful catalyst for various cross-coupling reactions. G3 precatalysts are versatile catalysts. They have long life in solution and are readily soluble in various organic solvents. G3- precatalysts have been employed in various C-N bond forming reactions.
Packaging:	1, 5 g in glass bottle
Packaging:	100, 250 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	180-186 °C
UNSPSC	12161600

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