Phosgene solution

ALDRICH/748684 - 15 wt. % in toluene

Synonym: Carbon oxychloride; Carbonyl chloride; Phosgen

CAS Number: 75-44-5
Empirical Formula (Hill Notation): CCl₂O
Molecular Weight: 98.92
MDL Number: MFCD00036119
Linear Formula: COCl₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-748684-4X25ML	25 mL	$116.00 4/EA		Add To Favorites
45-748684-100ML	100 mL	$123.00 1/EA		Add To Favorites

25 mL Sure/Seal™ Packaging

Properties
Descriptions
Safety Info.
Basic Data

concentration	15 wt. % in toluene
density	0.924 g/mL at 25 °C
form	liquid
InChI	1S/CCl2O/c2-1(3)4
InChI key	YGYAWVDWMABLBF-UHFFFAOYSA-N
Quality Level	200
SMILES string	ClC(Cl)=O
storage temp.	2-8°C

Application:	Phosgene solution (15 wt. % in toluene) has been used to synthesize the following peptide monomers: • γ-(4-propargyloxybenzyl)-L-glutamic acid N-carboxyanhydride (POB-L-Glu-NCA) • γ-(4,5-dimethoxy-2-nitrobenzyl)-L-glutamate N-carboxyanhydride (DMNB-L-Glu-NCA) • γ-(4,5-dimethoxy-2-nitrobenzyl)-D-glutamate N-carboxyanhydride (DMNB-D-Glu-NCA) • 2-nitrobenzyl(4-vinylphenyl)carbamate
Application:	Phosgene solution may be used in the synthesis of: • sulfonyl chlorides • Fmoc (Fluorenylmethyloxycarbonyl chloride)-taurylsulfonyl chloride • O-benzyl-L-serine carboxyanhydrides
General description:	Phosgene is used as a reagent in organic synthesis for various reactions such as carbonylation reaction and synthesis of isocyanates. Phosgene is formed during the free radical induced degradation of chlorinated hydrocarbons. Determination of phosgene in air samples using thermal desorption (TD) followed by gas chromatography-mass spectrometry (GC-MS) has been reported.
Legal Information:	Sure/Seal is a trademark of Sigma-Aldrich Co. LLC
Packaging:	4×25, 100 mL in Sure/Seal™
Packaging:	The 25 mL Sure/Seal^™ bottle is recommended as a single-use bottle. Repeated punctures will likely result in decreased performance of product.

Symbol	GHS02,GHS05,GHS06,GHS08
Signal word	Danger
Hazard statements	H225 - H304 - H314 - H330 - H336 - H361d - H373 - H412
Precautionary statements	P210 - P280 - P301 + P330 + P331 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338
Hazard Codes	F,T+
Risk Statements	63-11-26-34-48/20-65
Safety Statements	16-26-28-36/37/39-45-62
RIDADR	UN3489 - class 6.1 - PG 1 - acidic - RQ - Toxic by inhalation li
WGK Germany	WGK 2
Flash Point(F)	39.2 °F - closed cup
Flash Point(C)	4 °C - closed cup

Density	0.924 g/mL at 25 °C
Storage Temp.	2-8°C
UNSPSC	12352101

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