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Dibenzocyclooctyne-PEG4-maleimide

ALDRICH/760676 - for Copper-free Click Chemistry

Synonym: Polyethylene glycol; DBCO-PEG4-maleimide

Empirical Formula (Hill Notation): C36H42N4O9
Molecular Weight: 674.74
MDL Number: MFCD22572659
Linear Formula: C36H42N4O9
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-760676-1MG 1 mg
 $42.80
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45-760676-5MG 5 mg
 $143.00
1/EA		 Add To Favorites
45-760676-50MG 50 mg
 $492.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 760676-50MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 760676-5MG

 

form solid
functional group maleimide
InChI 1S/C36H42N4O9/c41-32(14-18-39-34(43)11-12-35(39)44)38-17-20-47-22-24-49-26-25-48-23-21-46-19-15-33(42)37-16-13-36(45)40-27-30-7-2-1-5-28(30)9-10-29-6-3-4-8-31(29)40/h1-8,11-12H,13-27H2,(H,37,42)(H,38,41)
InChI key VVFZXPZWVJMYPX-UHFFFAOYSA-N
reaction suitability reaction type: click chemistry
  reagent type: cross-linking reagent
SMILES string O=C(CCNC(CCOCCOCCOCCOCCNC(CCN1C(C=CC1=O)=O)=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4
storage temp. −20°C
Application: Maleimide functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into thiol containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. The PEG lipophilic spacer helps to reduce aggregation and precipitation problems when labeling biomolecules.
Applications Include:
• Protein-peptide conjugates
• Antibody-enzyme or antibody-drug conjugates
• Protein or peptide-oligonucleotide conjugates
• Surface modification
Packaging: 1, 5, 50 mg in amber glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 12161502

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