Dibenzocyclooctyne-PEG4-biotin conjugate

ALDRICH/760749 - for Copper-free Click Chemistry

Synonym: Polyethylene glycol; DBCO-PEG4-biotin

CAS Number: 1255942-07-4
Empirical Formula (Hill Notation): C₃₉H₅₁N₅O₈S
Molecular Weight: 749.92
MDL Number: MFCD22572661
Linear Formula: C₃₉H₅₁N₅O₈S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-760749-5MG	5 mg	$111.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

form	solid
InChI	1S/C39H51N5O8S/c45-35(12-6-5-11-34-38-32(28-53-34)42-39(48)43-38)41-18-20-50-22-24-52-26-25-51-23-21-49-19-16-36(46)40-17-15-37(47)44-27-31-9-2-1-7-29(31)13-14-30-8-3-4-10-33(30)44/h1-4,7-10,32,34,38H,5-6,11-12,15-28H2,(H,40,46)(H,41,45)(H2,42,43,48)/t32-,34-,38-/m0/s1
InChI key	LNHSQAOQVNHUGL-QRBHCBQLSA-N
reaction suitability	reaction type: click chemistry
SMILES string	O=C(CCCC[C@@H]1SC[C@@H]2NC(=O)N[C@H]12)NCCOCCOCCOCCOCCC(=O)NCCC(=O)N3Cc4ccccc4C#Cc5ccccc35
storage temp.	−20°C

Application:	Automate your Biotin tagging with Synple Automated Synthesis Platform (SYNPLE-SC002 )
Features and Benefits:	More efficient labeling will occur at higher temperatures and with greater excess of biotin reagent. Typical reaction times are up to 4 hours, but longer incubation periods should be used if concentration is low or if low labeling is observed. Product is most efficient when first dissolved in a water miscible organic solvent and then diluted in aqueous reaction buffer when needed. DBCO-PEG4-Biotin is soluble in aqueous buffers up to 0.35 mM.
General description:	This azadibenzocyclooctyne-biotin derivative is a versatile biotinylation reagent for labeling azide containing molecules or compounds. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions.This dibenzocyclooctyne will react with azide-functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. Subsequent labeled molecules can be purified using streptavidin or avidin affinity reagents. The PEG spacer makes the overall compound more hydrophilic and allows for greater distance between the reaction site with the azide and the biotin detecting group.
Other Notes:	2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research
Packaging:	5 mg in amber glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	−20°C
UNSPSC	12352003

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