Dibenzocyclooctyne-N-hydroxysuccinimidyl ester

ALDRICH/761524 - for Copper-free Click Chemistry

Synonym: DBCO-NHS ester; DBCO-SE

Empirical Formula (Hill Notation): C₂₃H₁₈N₂O₅
Molecular Weight: 402.40
MDL Number: MFCD24386367
Linear Formula: C₂₃H₁₈N₂O₅
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-761524-5MG	5 mg	$103.00 1/EA		Add To Favorites
45-761524-50MG	50 mg	$364.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

form	solid
functional group	NHS ester
InChI	1S/C23H18N2O5/c26-20(13-14-23(29)30-25-21(27)11-12-22(25)28)24-15-18-7-2-1-5-16(18)9-10-17-6-3-4-8-19(17)24/h1-8H,11-15H2
InChI key	XCEBOJWFQSQZKR-UHFFFAOYSA-N
mp	149-157 (decomposition)
reaction suitability	reaction type: click chemistry
	reagent type: cross-linking reagent
SMILES string	O=C(CCC(ON(C(CC1)=O)C1=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4
storage temp.	−20°C

Application:	Dibenzocyclooctyne-N-hydroxysuccinimidyl ester is commonly used:• In the modification and labeling of biomolecules such as antibodies and streptavidin by introducing DBCO groups onto their surfaces • As a cross linker to conjugate peptide antigens onto the surface of poly(lactic-co-glycolic acid) (PLGA) nanoparticles
General description:	DBCO-NHS ester is commonly used in bioconjugation. It consists of an NHS ester that reacts with primary amines on biomolecules and an alkyne group that allows for a specific reaction with molecules containing azides. This reaction is carried out through a copper-free click chemistry process called strain-promoted alkyne-azide cycloaddition.
Packaging:	1, 5, 50 mg in clear glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	149-157 (decomposition)
Storage Temp.	−20°C
UNSPSC	12352108

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