Dibenzocyclooctyne-N-hydroxysuccinimidyl ester
ALDRICH/761524 - for Copper-free Click Chemistry
Synonym: DBCO-NHS ester; DBCO-SE
Empirical Formula (Hill Notation): C23H18N2O5
Molecular Weight: 402.40
MDL Number: MFCD24386367
Linear Formula: C23H18N2O5
Product Type: Chemical
| form | solid |
| functional group | NHS ester |
| InChI | 1S/C23H18N2O5/c26-20(13-1 |
| InChI key | XCEBOJWFQSQZKR-UHFFFAOYSA |
| mp | 149-157 (decomposition) |
| Quality Level | 100  |
| reaction suitability | reaction type: click chemistry |
| reagent type: cross-linking reagent | |
| SMILES string | O=C(CCC(ON(C(CC1)=O)C1=O) |
| storage temp. | −20°C |
| Application: | Dibenzocyclooctyne-N-hydr • As a cross linker to conjugate peptide antigens onto the surface of poly(lactic-co-glycolic acid) (PLGA) nanoparticles |
| General description: | DBCO-NHS ester is commonly used in bioconjugation. It consists of an NHS ester that reacts with primary amines on biomolecules and an alkyne group that allows for a specific reaction with molecules containing azides. This reaction is carried out through a copper-free click chemistry process called strain-promoted alkyne-azide cycloaddition. |
| Packaging: | 1, 5, 50 mg in clear glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 149-157 (decomposition) |
| Storage Temp. | −20°C |
| UNSPSC | 12352108 |