Dibenzocyclooctyne-amine
ALDRICH/761540 - for Copper-free Click Chemistry
Synonym: DBCO-NH2; DBCO-amine
CAS Number: 1255942-06-3
Empirical Formula (Hill Notation): C18H16N2O
Molecular Weight: 276.33
MDL Number: MFCD22380759
Linear Formula: C18H16N2O
Product Type: Chemical
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 761540-100MG
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 761540-10MG
| form | solid |
| functional group | amine |
| InChI | 1S/C18H16N2O/c19-12-11-18 |
| InChI key | OCCYFTDHSHTFER-UHFFFAOYSA |
| mp | 86-96 °C |
| reaction suitability | reaction type: click chemistry |
| reagent type: linker | |
| SMILES string | NCCC(N1CC2=C(C=CC=C2)C#CC |
| storage temp. | −20°C |
| Application: | Dibenzocyclooctyne-amine can be used as a :• Linker to link azide-containing functional groups. It facilitates the formation of linkages through Strain-promoted azide-alkyne cycloaddition reactions (SPAAC) • Reagent in the synthesis of N-heterocyclic carbene metal thiolates. It functionalizes the metal complexes and increases their reactivity in the strain-promoted alkyne–azide cycloaddition (SPAAC) reactions • Amine functionalized cyclooctyne derivative. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage. |
| General description: | Dibenzocyclooctyne-amine (DBCO-NH2), is a heterobifunctional linker containing a DBCO moiety commonly used for the site-specific functionalization of nanobodies, enabling the addition of reactive DBCO groups for subsequent click chemistry reactions. |
| Packaging: | 10, 100 mg in amber glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| mp | 86-96 °C |
| Storage Temp. | −20°C |
| UNSPSC | 12352116 |