Dibenzocyclooctyne-sulfo-N-hydroxysuccinimidyl ester

ALDRICH/762040 - for Copper-free Click Chemistry

Synonym: DBCO-sulfo-NHS ester; DBCO-sulfo-SE

Empirical Formula (Hill Notation): C₂₅H₂₁N₂NaO₈S
Molecular Weight: 532.50
MDL Number: MFCD22572669
Linear Formula: C₂₅H₂₁N₂NaO₈S
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-762040-1MG	1 mg	$43.70 1/EA		Add To Favorites
45-762040-5MG	5 mg	$157.00 1/EA		Add To Favorites
45-762040-50MG	50 mg	$492.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

form	solid
InChI	1S/C25H22N2O8S.Na/c28-22(11-5-6-12-24(30)35-27-23(29)15-21(25(27)31)36(32,33)34)26-16-19-9-2-1-7-17(19)13-14-18-8-3-4-10-20(18)26;/h1-4,7-10,21H,5-6,11-12,15-16H2,(H,32,33,34);/q;+1/p-1
InChI key	QXKHPYSXPCJSPR-UHFFFAOYSA-M
mp	240-260 °C
reaction suitability	reaction type: click chemistry
	reagent type: linker
SMILES string	O=C(CCCCC(ON(C(CC1S(=O)(O[Na])=O)=O)C1=O)=O)N2CC3=C(C=CC=C3)C#CC4=C2C=CC=C4
storage temp.	−20°C

Application:	Water soluble succinimidyl ester/NHS functionalized cyclooctyne derivative for incorporation of the cyclooctyne moiety into amine containing compounds or biomolecules. Cyclooctynes are useful in strain-promoted copper-free azide-alkyne cycloaddition reactions. This dibenzocyclooctyne will react with azide functionalized compounds or biomolecules without the need for a Cu(I) catalyst to result in a stable triazole linkage.
Application:	Dibenzocyclooctyne-sulfo-N-hydroxysuccinimidyl ester may be used for the covalent modification of nano-sized metal-organic frameworks (NMOFs) with nucleic acids via click chemistry during the synthesis stimuli-responsive DNA-gated NMOFs. These NMOFs can act as carriers of a fluorescent agent or anticancer drug, making them highly useful in targeted drug release system.
Packaging:	1, 5, 50 mg in clear glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

mp	240-260 °C
Storage Temp.	−20°C
UNSPSC	12352108

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