Alkyne-PEG5-N-hydroxysuccinimidyl ester
ALDRICH/764191
Synonym: Acetylene-PEG5-NHS ester; Alkyne-PEG5-NHS ester; Alkyne-
Empirical Formula (Hill Notation): C18H27NO9
Molecular Weight: 401.41
MDL Number: MFCD22574798
Linear Formula: C18H27NO9
Product Type: Chemical
| form | liquid |
| functional group | alkyne |
| NHS ester | |
| InChI | 1S/C18H27NO9/c1-2-6-23-8- |
| InChI key | ACZDUKRWTPZVRP-UHFFFAOYSA |
| Quality Level | 100  |
| reaction suitability | reaction type: click chemistry |
| reagent type: cross-linking reagent | |
| SMILES string | C#CCOCCOCCOCCOCCOCCC(ON1C |
| storage temp. | −20°C |
| Application: | Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a primary amine. The succinimidyl ester group will react preferentially with primary amines to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification amine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character. |
| Packaging: | 10, 25 mg in clear glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352108 |