Alkyne-PEG4-maleimide
ALDRICH/764205 - 90% (HPLC)
Synonym: Acetylene-
Empirical Formula (Hill Notation): C18H26N2O7
Molecular Weight: 382.41
MDL Number: MFCD22380740
Linear Formula: C18H26N2O7
Product Type: Chemical
| assay | 90% (HPLC) |
| form | liquid |
| functional group | alkyne |
| maleimide | |
| InChI | 1S/C18H26N2O7/c1-2-8-24-1 |
| InChI key | GHEBECZRHJXPTL-UHFFFAOYSA |
| mp | 62-67 °C |
| reaction suitability | reaction type: click chemistry |
| reagent type: cross-linking reagent | |
| SMILES string | O=C(N1CCC(NCCOCCOCCOCCOCC |
| storage temp. | −20°C |
| Application: | Alkyne-PEG4-maleimide has been used for modification of Csy containing bacterial collagens by introducing alkyne moiety to enable it for further chemical modification. |
| Application: | Heterobifunctional crosslinker enabling the connection of an azide containing compound or biomolecule to one with a thiol. The maleimide group will react preferentially with thiols to form a covalent adduct and the terminal alkyne will react with azides via copper-catalyzed 1,3-dipolar cycloaddition click chemistry. The hydrophilic PEG spacer adds to the water solubility of this reagent, allowing for easy modification cysteine containing biomolecules such as antibodies, proteins and peptides with the terminal alkyne. The PEG spacer also reduces aggregation of modified proteins stored in solution by adding hydrophilic character. |
| Packaging: | 10, 25 mg in amber glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 90% (HPLC) |
| mp | 62-67 °C |
| Storage Temp. | −20°C |
| UNSPSC | 12352111 |