(E)-Cyclooct-4-enol
ALDRICH/764396
Synonym: (4E)-4-Cycloocten-1-ol; trans-Cyclooctenol; TCO-OH; rel-(1R,4E,pR)-Cyclooct-4-enol
CAS Number: 85081-69-2
Empirical Formula (Hill Notation): C8H14O
Molecular Weight: 126.20
Linear Formula: C8H14O
Product Type: Chemical
| form | liquid |
| functional group | hydroxyl |
| InChI | 1S/C8H14O/c9-8-6-4-2-1-3- |
| InChI key | UCPDHOTYYDHPEN-CMLYIYFCSA |
| reaction suitability | reaction type: click chemistry |
| reagent type: linker | |
| SMILES string | O[C@H]1CC/C=C/CCC1 |
| storage temp. | −20°C |
| Application: | (E)-Cyclooct-4-enol may be used in the multi-step synthesis of trans-cyclooctene geranyl diphosphate, a novel strained-ring containing protein farnesyltransferase (PFTase) substrate that can be used in site-specific modification technologies. |
| Application: | Hydroxyl modified cyclooctene derivative. Cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1,2,4,5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging. |
| Packaging: | 10, 50 mg in glass bottle |
| Symbol |  GHS05 |
| Signal word | Danger |
| Hazard statements | H318 |
| Precautionary statements | P280 - P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Statements | 41-52 |
| Safety Statements | 26-39 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352200 |