Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)-block-decane
ALDRICH/764736 - PEG average Mn 2,000, PDLLA average Mn 2,000
Synonym: PEG-PDLLA-decane; PEG-b-PLA-b-decane; PEG-PLA
Product Type: Chemical
| degradation timeframe | 2-5 weeks |
| form | pellets |
| mol wt | average Mn 4,000 (total) |
| PDLLA average Mn 2,000 | |
| PEG average Mn 2,000 | |
| PDI | <1.1 (typical PEG) |
| <1.2 | |
| <1.3 (overall) | |
| storage temp. | 2-8°C |
| transition temp | Tm 29-33 °C |
| Application: | Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs. |
| Features and Benefits: | • Good biocompatibility, low immunogenicity and good degradability. • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application. |
| General description: | Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as a carrier for hydrophobic drugs like Paclitaxel. The hydrophilic PEG and hydrophobic PDLLA form the micelle core wherein the hydrophobic drug is loaded. The incorporation of the 10-alkyl end cap (decane) increases the hydrophobicity of the micelle core and increases its solubilizing capability for hydrophobic drugs.† |
| Packaging: | 1 g in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | > 230.0 °F |
| Flash Point(C) | > 110 °C |
| Storage Temp. | 2-8°C |
| UNSPSC | 12162002 |