Poly(lactide-co-glycolide)-block-poly(ethylene glycol)-block-poly(lactide-co-glycolide)
ALDRICH/764817 - average Mn (1100-1000-1100), lactide:glycolide 75:25
Synonym: PLGA-PEG-PLGA
Product Type: Chemical
| degradation timeframe | 2-3 weeks |
| description | typical PEG PDI<1.1; overall PDI≤2.0 (THF, PS) |
| feed ratio | lactide:glycolide 75:25 |
| form | semisolid |
| mol wt | average Mn (1100-1000-1100) |
| PEG average Mn 1,000 | |
| PLGA average Mn 2,200 | |
| PDI | <2.0 |
| storage temp. | 2-8°C |
| transition temp | Tm 230-235 °C |
| Application: | Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs. |
| Features and Benefits: | Biocompatible, degradable, thermosensitive, high stability, small size (<200 nm) and properties can be easily modified. |
| General description: | PLGA-PEG-PLGA is an amphiphilic triblock copolymer which can self-assemble into micelles in aqueous medium due to the hydrophobic interactions present in the hydrophobic segments. The PEG segment imparts hydrophilicity and improves the biocompatibility of the copolymer. The PLGA segment forms a hydrophobic core and can solubilize hydrophobic drugs. These copolymers are widely used as nanocarriers for the sustained release of drugs. |
| Packaging: | 1 g in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12162002 |