Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide)
ALDRICH/764825 - PEG Mn 2,000, PLGA Mn 4,500
Synonym: PEG-PLGA; Polyethylene glycol; mPEG-b-PLGA
Linear Formula: H[(C3H4O2)x(C2H2O2)y]mO[C2H4O]nCH3
Product Type: Chemical
| degradation timeframe | 1-4 weeks |
| feed ratio | lactide:glycolide 65:35 |
| form | pellets |
| mol wt | average Mn 6,500 (total) |
| PEG Mn 2,000 | |
| PLGA Mn 4,500 | |
| PDI | ≤2.0 |
| storage temp. | 2-8°C |
| transition temp | Tm 241-246 °C |
| Application: | forming "stealth" pegylated microparticles |
| Application: | Used in the synthesis of targeted nanoparticles which are used for differential delivery and controlled release of drugs. |
| Features and Benefits: | • Good biocompatibility, low immunogenicity and good degradability. • Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application. |
| General description: | Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part. |
| Packaging: | 1 g in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 12162002 |