Lithium bis(trimethylsilyl)amide solution
ALDRICH/766917 - 1.5 M in THF
Synonym: Hexamethyldisilazane lithium salt
CAS Number: 4039-32-1
Empirical Formula (Hill Notation): C6H18LiNSi2
Molecular Weight: 167.33
MDL Number: MFCD00008261
Linear Formula: [(CH3)3Si]2NLi
Product Type: Chemical
| concentration | 1.5 M in THF |
| density | 0.893 g/mL at 25 °C |
| form | liquid |
| InChI | 1S/C6H18NSi2.Li/c1-8(2,3) |
| InChI key | YNESATAKKCNGOF-UHFFFAOYSA |
| Quality Level | 100  |
| SMILES string | [Li]N([Si](C)(C)C)[Si](C) |
| Application: | Lithium bis(trimethylsilyl)amide can be used as a reagent: • In the deprotonation and nucleophilic difluoromethylation reactions. • 3-methoxy substituted dihydropyrrole derivatives by reacting with aldehydes and lithiated methoxyallene via in situ formations of N-trimethylsilylated imines. • In Darzens condensation and directed aldol condensation reactions. • To synthesize poly(N-octyl-p-benzamide)s by chain-growth polycondensation of 4-octylaminobenzoic acid methyl ester. |
| General description: | Lithium bis(trimethylsilyl)amide is commonly used in organic synthesis as a non-nucleophilic strong Bronsted base. It is soluble in most nonpolar solvents such as aromatic hydrocarbons, hexanes, and THF. |
| Packaging: | 100, 800 mL in Sure/Seal™ |
| Symbol |     GHS02,GHS05,GHS07,GHS08 |
| Signal word | Danger |
| Hazard statements | H225 - H314 - H335 - H351 |
| Precautionary statements | P210 - P260 - P280 - P305 + P351 + P338 - P370 + P378 - P403 + P235 |
| Hazard Codes | F,C |
| Risk Statements | 11-14-19-34-37-40 |
| Safety Statements | 16-26-36/37/39-45 |
| RIDADR | UN 2924 8(3) / PGII |
| WGK Germany | WGK 1 |
| Flash Point(F) | 31.3 °F - closed cup |
| Flash Point(C) | -0.4 °C - closed cup |
| Supplemental Hazard Statements | EUH014 - EUH019 |
| Density | 0.893 g/mL at 25 °C |
| UNSPSC | 12352111 |