Synonym: N-α-Fmoc-N-α-methyl-S-trityl-L-cysteine
CAS Number: 944797-51-7
Empirical Formula (Hill Notation): C38H33NO4S
Molecular Weight: 599.74
Linear Formula: C38H33NO4S
Product Type: Chemical
application(s) | peptide synthesis |
assay | 97% (HPLC) |
form | powder or crystals |
functional group | Fmoc |
InChI | 1S/C38H33NO4S/c1-39(37(42 |
InChI key | RAKOPMQMPUNRGI-DHUJRADRSA |
mp | 234-239 °C |
optical activity | [α]22/D -25.0°, c = 0.5% in dichloromethane |
Quality Level | 100 ![]() |
reaction suitability | reaction type: Fmoc solid-phase peptide synthesis |
storage temp. | 2-8°C |
Application: | Fmoc-N-Me-Cys(Trt)-OH is a Fmoc-protected derivative of N-methyl cysteine used as a building block to prepare peptide thioesters under acidic conditions. The residue attached to the amino group of N-methylcysteine can migrate to the cysteinyl thiol group, resulting in the formation of a peptide thioester. The introduction of this Fmoc-protected derivative is best achieved using HATU as a coupling reagent in the presence of DIPEA (N, N-Diisopropylethylamine). It can also be used to prepare Fmoc-N-Me-Cys(Trt)-OAllyl intermediate for the solid-phase synthesis of dithiol Triostin A. |
Packaging: | 1 g in glass bottle |
Packaging: | 250 mg in glass bottle |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | 97% (HPLC) |
mp | 234-239 °C |
Storage Temp. | 2-8°C |
UNSPSC | 12352209 |
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