Fmoc-N-Me-Cys(Trt)-OH
ALDRICH/773069 - 97% (HPLC)
Synonym: N-α-Fmoc-N-α-methyl-S-trityl-L-cysteine
CAS Number: 944797-51-7
Empirical Formula (Hill Notation): C38H33NO4S
Molecular Weight: 599.74
MDL Number: MFCD11973909
Linear Formula: C38H33NO4S
Product Type: Chemical
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| application(s) | peptide synthesis |
| assay | 97% (HPLC) |
| form | powder or crystals |
| functional group | Fmoc |
| InChI | 1S/C38H33NO4S/c1-39(37(42 |
| InChI key | RAKOPMQMPUNRGI-DHUJRADRSA |
| mp | 234-239 °C |
| optical activity | [α]22/D -25.0°, c = 0.5% in dichloromethane |
| Quality Level | 100  |
| reaction suitability | reaction type: Fmoc solid-phase peptide synthesis |
| SMILES string | S(C[C@H](N(C)C(=O)OCC4c5c |
| storage temp. | 2-8°C |
| Application: | Fmoc-N-Me-Cys(Trt)-OH is a Fmoc-protected derivative of N-methyl cysteine used as a building block to prepare peptide thioesters under acidic conditions. The residue attached to the amino group of N-methylcysteine can migrate to the cysteinyl thiol group, resulting in the formation of a peptide thioester. The introduction of this Fmoc-protected derivative is best achieved using HATU as a coupling reagent in the presence of DIPEA (N, N-Diisopropylethylamine). It can also be used to prepare Fmoc-N-Me-Cys(Trt)-OAllyl intermediate for the solid-phase synthesis of dithiol Triostin A. |
| Packaging: | 1 g in glass bottle |
| Packaging: | 250 mg in glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | 97% (HPLC) |
| mp | 234-239 °C |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352209 |