3-(2-Acetoxy-4,6-dimethylphenyl)-3-methylbutyric acid N-succinimidyl ester

ALDRICH/776181 - 95%

Synonym: 3-(2-Acetoxy-4,6-dimethylphenyl)-3-methylbutyric acid N-hydroxysuccinimide ester; Trimethyl lock NHS; Trimethyl lock succinimidyl ester

Empirical Formula (Hill Notation): C₁₉H₂₃NO₆
Molecular Weight: 361.39
MDL Number: MFCD24386387
Linear Formula: C₁₉H₂₃NO₆
Product Type: Chemical

assay	95%
form	solid
InChI	1S/C19H23NO6/c1-11-8-12(2)18(14(9-11)25-13(3)21)19(4,5)10-17(24)26-20-15(22)6-7-16(20)23/h8-9H,6-7,10H2,1-5H3
InChI key	KMNOKEFBKJGRFL-UHFFFAOYSA-N
mp	107-112 °C
Quality Level	100
SMILES string	CC(=O)Oc1cc(C)cc(C)c1C(C)(C)CC(=O)ON2C(=O)CCC2=O
storage temp.	2-8°C

Application:	This ′trimethyl lock′ derivative is activated with a succinimidyl ester for modification of amine containing compounds and biomolecules. After modification of your amine of interest, your now ′masked′ molecule can be released by cleavage of the ester, which can be achieved by cellular esterases. This triggers a rapid lactonization reaction of the ′trimethyl lock′ to regenerate your original amine-containing molecule. This approach has been applied to release of fluorophores, peptides, nucleic acids as well as small molecule drugs.
Packaging:	250 mg in amber glass bottle
Packaging:	50 mg in clear glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H302
Hazard Codes	Xn
Risk Statements	22
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable