(2-Hydroxypropyl)-β-cyclodextrin

ALDRICH/778966 - produced by Wacker Chemie AG, Burghausen, Germany

Synonym: (2-Hydroxypropyl)-beta-cyclodextrin; Cavasol^® W7 HP; HP-β-CD

CAS Number: 128446-35-5
EC Number: 420-920-1
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-778966-100G	100 g	$341.00 1/EA		Add To Favorites
45-778966-500G	500 g	$828.00 1/EA		Add To Favorites
45-778966-10KG	10 kg	$6440.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

extent of labeling	molar substitution per 0.60
form	powder
grade	produced by Wacker Chemie AG, Burghausen, Germany
ign. residue	≤2.5%
impurities	≤1.0% unsubstituted cyclodextrin
	≤5.0% polypropylene glycol
InChI	1S/C63H112O42/c1-22(64)8-85-15-29-50-36(71)43(78)57(92-29)100-51-30(16-86-9-23(2)65)94-59(45(80)38(51)73)102-53-32(18-88-11-25(4)67)96-61(47(82)40(53)75)104-55-34(20-90-13-27(6)69)98-63(49(84)42(55)77)105-56-35(21-91-14-28(7)70)97-62(48(83)41(56)76)103-54-33(19-89-12-26(5)68)95-60(46(81)39(54)74)101-52-31(17-87-10-24(3)66)93-58(99-50)44(79)37(52)72/h22-84H,8-21H2,1-7H3/t22?,23?,24?,25?,26?,27?,28?,29-,30-,31?,32?,33?,34?,35?,36?,37-,38?,39-,40+,41+,42+,43?,44+,45?,46+,47+,48+,49+,50+,51+,52-,53-,54-,55-,56-,57+,58-,59+,60-,61-,62-,63-/m1/s1
InChI key	ODLHGICHYURWBS-RYJYQAAZSA-N
loss	≤7.0% loss on drying
SMILES string	CC(O)COCC1OC2OC3C(COCC(C)O)OC(OC4C(COCC(C)O)OC(OC5C(COCC(C)O)OC(OC6C(COCC(C)O)OC(OC7C(COCC(C)O)OC(OC8C(COCC(C)O)OC(OC1C(OCC(C)O)C2OCC(C)O)C(OCC(C)O)C8OCC(C)O)C(OCC(C)O)C7OCC(C)O)C(OCC(C)O)C6OCC(C)O)C(OCC(C)O)C5OCC(C)O)C(OCC(C)O)C4OCC(C)O)C(OCC(C)O)C3OCC(C)O

Application:	2-Hydroxypropyl)-β-cyclodextrin is used as a:• Macromolecular additive in the synthesis of single-phasetetragonal zirconium oxides. • Precursor in the synthesis of polyrotaxane. • Solubilizer and stabilizer in pharmaceutical formulations. HP-β-CD also shows potent anticancer activity.
Application:	The solubility of lipophilic drugs increases linearly with the concentration of hydroxypropyl-β-cyclodextrin (HBC) in aqueous solution because of the complex between HBC and the drug. This guest-host type complex is formed between the drug and the non-polar cavity in the HBC that results in enhanced solubility. Solutions may be lyophilized to produce freely soluble powders. Non-toxic in rabbits and mice.
General description:	(2-Hydroxypropyl)- β -cyclodextrin (HP-β-CD), is a macrocyclic oligosaccharide with a hydrophobic inner cavity and a hydrophilic outer surface, that allows it to incorporate hydrophobic drugs into the cavities, thus enhancing water solubility and bioavailability of poorly water-soluble drugs. It also possesses high surface activity and stabilizing performance.
Legal Information:	Cavasol is a registered trademark of Wacker Chemie AG

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

UNSPSC

12352201

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