TCO PEG4 succinimidyl ester
ALDRICH/790435
Synonym: trans-
Empirical Formula (Hill Notation): C24H38N2O10
Molecular Weight: 514.57
MDL Number: MFCD28118912
Linear Formula: C24H38N2O10
Product Type: Chemical
| form | liquid |
| functional group | NHS ester |
| InChI | 1S/C24H38N2O10/c27-21-8-9 |
| InChI key | ZKPMRASGLDBKPF-OWOJBTEDSA |
| reaction suitability | reaction type: click chemistry |
| reagent type: linker | |
| SMILES string | O=C(NCCOCCOCCOCCOCCC(ON1C |
| storage temp. | −20°C |
| Application: | Succinimidyl ester/NHS (amine reactive) functionalized trans-cyclooctene derivative for incorporation of the cyclooctene moiety into amine containing compounds or biomolecules. Trans-cyclooctenes are useful in strain-promoted, copper-free, click chemistry cycloaddition reactions with 1, 2, 4, 5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules, without the need for a catalyst, to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported, and has had many applications in biological labeling and imaging. The PEG spacer allows for increased water solubility, less aggregation, and an increased distance between the amine to be modified and the reactive alkene. |
| Packaging: | 5, 25 mg in clear glass bottle |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352108 |