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TCO-PEG3-maleimide

ALDRICH/790443

Synonym: trans-Cyclooctene-maleimide

Empirical Formula (Hill Notation): C26H41N3O8
Molecular Weight: 523.62
MDL Number: MFCD28053553
Linear Formula: C26H41N3O8
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-790443-5MG 5 mg
 $305.00
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45-790443-25MG 25 mg
 $752.00
1/EA		 Add To Favorites

 

form liquid
functional group maleimide
InChI 1S/C26H41N3O8/c30-23(12-15-29-24(31)10-11-25(29)32)27-13-6-16-34-18-20-36-21-19-35-17-7-14-28-26(33)37-22-8-4-2-1-3-5-9-22/h1-2,10-11,22H,3-9,12-21H2,(H,27,30)(H,28,33)/b2-1+
InChI key BJZRPWAVCDJCTC-OWOJBTEDSA-N
Quality Level 100 
reaction suitability reaction type: click chemistry
  reagent type: linker
SMILES string O=C(NCCCOCCOCCOCCCNC(CCN1C(C=CC1=O)=O)=O)OC2CCC/C=C/CC2
storage temp. −20°C
Biochem/physiol Actions: Maleimide (thiol reactive) functionalized trans-cyclooctene derivative for incorporation of the cyclooctene moiety into thiol containing compounds or biomolecules. Trans-cyclooctenes are useful in strain-promoted copper-free click chemistry cycloaddition reactions with 1; 2; 4; 5-tetrazines. This cyclooctene will react with tetrazine functionalized compounds or biomolecules without the need for a catalyst to result in a stable covalent linkage. The 4+2 inverse electron demand Diels-Alder cycloaddition between trans-cyclooctene and tetrazines is the fastest biologically compatible ligation technology reported and has had many applications in biological labeling and imaging. The PEG spacer allows for increased water solubility; less aggregation and an increased distance between the thiol to be modified and the reactive alkene.
Packaging: 5, 25 mg in clear glass bottle
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Storage Temp. −20°C
UNSPSC 12352111

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