Yu-Wasa Auxiliary

ALDRICH/791806 - 97%

Synonym: 2,3,5,6-Tetrafluoro-4-(trifluoromethyl)aniline; 2,3,5,6,α,α,α-Heptafluoro-p-toluidine

CAS Number: 651-83-2
Empirical Formula (Hill Notation): C₇H₂F₇N
Molecular Weight: 233.09
MDL Number: MFCD00091518
Linear Formula: CF₃C₆F₄NH₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-791806-10G	10 g	$329.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	97%
bp	186 °C (lit.)
density	1.662 g/mL at 25 °C
	1.687 g/mL at 25 °C (lit.)
form	liquid
InChI	1S/C7H2F7N/c8-2-1(7(12,13)14)3(9)5(11)6(15)4(2)10/h15H2
InChI key	FJOACTZFMHZHSC-UHFFFAOYSA-N
reaction suitability	reaction type: C-C Bond Formation
	reagent type: catalyst reaction type: C-H Activation
refractive index	n20/D 1.431 (lit.)
	n20/D 1.432
SMILES string	Nc1c(F)c(F)c(c(F)c1F)C(F)(F)F

Other Notes:

Acidic amides are superior directing groups for promoting C-H activation reactions with both Pd(0)/PR₃ and Pd(II) catalysts.

Used in the Preparation of
• Lactams via palladium-catalyzed olefination of arylamides with benzylacrylate, followed by 1,4-conjugate addition
• N-(fluorinated aryl)benzamides as substrates for regioselective C-H amination reactions with O-benzoylhydroxylamines
• Substituted succinimides via palladium-catalyzed carbonylation of N-aryl amides
• N-aryl cyclopropanecarboxamide substrates and various amino acid ligands for palladium-catalyzed C-H activation of cyclopropanes

Packaging:

1, 10 g in poly bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	97%
bp	186 °C (lit.)
Density	1.662 g/mL at 25 °C; 1.687 g/mL at 25 °C (lit.)
Refractive Index	n20/D 1.431 (lit.); n20/D 1.432
UNSPSC	12352101

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