2-Chloro-2,2-difluoroacetophenone

ALDRICH/792373 - 95%

Synonym: 2-Chloro-2,2-difluoro-1-phenylethanone; Chlorodifluoromethyl phenyl ketone; α-Chloro-α,α-difluoroacetophenone

CAS Number: 384-67-8
Empirical Formula (Hill Notation): C₈H₅ClF₂O
Molecular Weight: 190.57
MDL Number: MFCD00042123
Linear Formula: C₆H₅COCF₂Cl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-792373-10G	10 g	$308.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	95%
bp	94-96 °C/35 mmHg (lit.)
density	1.293 g/mL at 25 °C (lit.)
	1.3178 g/mL at 25 °C
form	liquid
InChI	1S/C8H5ClF2O/c9-8(10,11)7(12)6-4-2-1-3-5-6/h1-5H
InChI key	MNOONJNILVDLSW-UHFFFAOYSA-N
reaction suitability	reaction type: C-C Bond Formation
refractive index	n20/D 1.4954
	n20/D 1.497 (lit.)
SMILES string	FC(F)(Cl)C(=O)c1ccccc1

Application:	2-Chloro-2,2-difluoroacetophenone can be used: • As a reagent in the difluoromethylation of various phenols to yield aryl difluoromethyl ethers. • As a precursor in the Baylis-Hillman reaction of fluoroalkyl ketones to obtain chlorodifluoromethyl containing products. • As a substrate in the synthesis of propargyl alcohols using a novel ruthenium catalyst.
Application:	Reagent is an effective product for the synthesis of difluoromethylated phenols in the presence of mild base and aqueous solvent.
General description:	2-Chloro-2,2-difluoroacetophenone is a difluorocarbene reagent, which is generally used in the synthesis of 2,2-difluoro enol silyl ethers, and gem -difluoromethene derived compounds.
Packaging:	1, 10 g in glass bottle

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-36
RIDADR	UN 3334
WGK Germany	WGK 3
Flash Point(F)	160.0 °F
Flash Point(C)	71.1 °C

Purity	95%
bp	94-96 °C/35 mmHg (lit.)
Density	1.293 g/mL at 25 °C (lit.); 1.3178 g/mL at 25 °C
Refractive Index	n20/D 1.4954; n20/D 1.497 (lit.)
UNSPSC	12352101

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