HandaPhos

ALDRICH/799580 - ≥95%

Synonym: (2S,3S)-4-(2,6-Dimethoxyphenyl)-3-(2-methyl-2-propanyl)-2-(2,4,6-triisopropylbenzyl)-2,3-dihydro-1,3-benzoxaphosphole

CAS Number: 1908442-13-6
Empirical Formula (Hill Notation): C₃₅H₄₇O₃P
Molecular Weight: 546.72
Linear Formula: C₃₅H₄₇O₃P
Product Type: Chemical

12 Principles of Green Chemistry: Principle 9—Catalytic reagents (as selective as possible) are superior to stoichiometric reagents.

assay	≥95%
form	powder
functional group	phosphine
greener alternative category	Aligned ,
greener alternative product characteristics	Catalysis Learn more about the Principles of Green Chemistry .
Quality Level	100
reaction suitability	reaction type: Buchwald-Hartwig Cross Coupling Reaction
	reaction type: Heck Reaction
	reaction type: Hiyama Coupling
	reaction type: Negishi Coupling
	reaction type: Sonogashira Coupling
	reaction type: Stille Coupling
	reaction type: Suzuki-Miyaura Coupling
	reagent type: ligand
SMILES string	COC(C=CC=C1OC)=[C@]1[C@@]2=C([P@](C(C)(C)C)[C@@H](CC3=C(C(C)C)C=C(C(C)C)C=C3C(C)C)O4)C4=CC=C2
storage temp.	2-8°C
sustainability	Greener Alternative Product

Application:	HandaPhos forms a 1:1 complex with Pd(OAc)₂ thereby arriving at a pre-catalyst, used at the ppm level, that enables Suzuki-Miyaura cross-couplings to be run under micellar catalysis in water at room temperature. To be used in tandem with Designer Surfactant TPGS-750-M.
General description:	We are committed to bringing you Greener Alternative Products, which adhere to one or more of The 12 Principles of Greener Chemistry. This product has been enhanced for catalytic efficiency. Click here for more information.
Other Notes:	HandaPhos: A General Ligand Enabling Sustainable ppm Levels of Palladium-Catalyzed Cross-Couplings in Water at Room Temperature
Other Notes:	Watch Professor Lipshutz talk about HandaPhos in this webinar: From milligrams to kilograms: synthetic chemistry following nature′s lead
Packaging:	25, 100, 250 mg in glass bottle