AlPhos

ALDRICH/799718

Synonym: Di-1-adamantyl(4″-butyl-2″,3″,5″,6″-tetrafluoro-2′,4′,6′-triisopropyl-2-methoxy-meta-terphenyl)phosphine

CAS Number: 1805783-60-1
Empirical Formula (Hill Notation): C₅₂H₆₇F₄OP
Molecular Weight: 815.06
Linear Formula: C₅₂H₆₇F₄OP
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-799718-100MG	100 mg	$179.00 1/EA	Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
form	powder
functional group	phosphine
InChI	1S/C52H67F4OP/c1-9-10-12-38-46(53)48(55)45(49(56)47(38)54)44-40(29(4)5)21-39(28(2)3)43(42(44)30(6)7)37-13-11-14-41(57-8)50(37)58(51-22-31-15-32(23-51)17-33(16-31)24-51)52-25-34-18-35(26-52)20-36(19-34)27-52/h11,13-14,21,28-36H,9-10,12,15-20,22-27H2,1-8H3/t31-,32+,33?,34-,35+,36?,51+,52?,58?
InChI key	ALWIRDZSIXWCBO-VABCSHEKSA-N
mp	218-223 °C
Quality Level	100
reaction suitability	reaction type: Buchwald-Hartwig Cross Coupling Reaction
	reaction type: Heck Reaction
	reaction type: Hiyama Coupling
	reaction type: Negishi Coupling
	reaction type: Sonogashira Coupling
	reaction type: Stille Coupling
	reaction type: Suzuki-Miyaura Coupling
	reagent type: ligand reaction type: Cross Couplings
storage temp.	−20°C

Application:

AlPhos is a biaryl monophosphine ligand that can be used:
• In the Pd-catalyzed Buchwald-Hartwig cross-coupling reactions.
• To synthesize highly regioselective aryl fluorides by Pd-catalyzed fluorination of a variety of activated aryl and heteroaryl triflates and bromides.
• To prepare aryl thioethers by C–S cross-coupling of thiols with aromatic electrophile in the presence of palladium catalyst.

Packaging:

100 mg in glass bottle

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3

Purity	≥95%
mp	218-223 °C
Storage Temp.	−20°C
UNSPSC	12161600

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