2-(Pyridin-2-yl)isopropyl amine
ALDRICH/802166 - 95% (GC)
Synonym: PIP; PIP Directing Group; Shi Auxilliary
CAS Number: 52568-28-2
Empirical Formula (Hill Notation): C8H12N2
Molecular Weight: 136.19
MDL Number: MFCD08729302
Linear Formula: C8H12N2
Product Type: Chemical
assay | 95% (GC) |
density | 0.9800 g/mL at 25 °C |
description | Fp: 175°F |
form | liquid |
InChI | 1S/C8H12N2/c1-8(2,9)7-5-3 |
InChI key | DQSQBZXDMHDHEO-UHFFFAOYSA |
Quality Level | 100 |
reaction suitability | reagent type: catalyst |
reagent type: ligand reaction type: C-H Activation |
|
refractive index | n |
SMILES string | NC(C)(C)C1=CC=CC=N1 |
Application: | The Shi Auxiliary is a powerful directing group for the hydroxylation of arenes through copper-mediated C-H activation. This useful auxiliary can be removed through acid-mediated hydrolysis and has shown to be done on gram-scale. |
General description: | 2-(Pyridin-2-yl)isopropyl amine (PIP-amine) is a tertiary amine. A bidentate directing group, useful for the functionalization of C-H bond, has been developed from PIP-amine. |
Other Notes: | Copper-Mediated Hydroxylation of Arenes and Heteroarenes Directed by a Removable Bidentate Auxiliary |
Packaging: | 500 mg in glass bottle |
Symbol | GHS07 |
Signal word | Warning |
Hazard statements | H302 - H315 - H319 |
Precautionary statements | P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 |
WGK Germany | WGK 3 |
Flash Point(F) | 175.0 °F |
Flash Point(C) | 79.44 °C |
Purity | 95% (GC) |
Density | 0.9800 g/mL at 25 °C |
Refractive Index | n |
UNSPSC | 12352100 |