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2-(Pyridin-2-yl)isopropyl amine

ALDRICH/802166 - 95% (GC)

Synonym: PIP; PIP Directing Group; Shi Auxilliary

CAS Number: 52568-28-2
Empirical Formula (Hill Notation): C8H12N2
Molecular Weight: 136.19
MDL Number: MFCD08729302
Linear Formula: C8H12N2
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-802166-500MG 500 mg
$94.40
1/EA
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assay 95% (GC)
density 0.9800 g/mL at 25 °C
description Fp: 175°F
form liquid
InChI 1S/C8H12N2/c1-8(2,9)7-5-3-4-6-10-7/h3-6H,9H2,1-2H3
InChI key DQSQBZXDMHDHEO-UHFFFAOYSA-N
Quality Level 100 
reaction suitability reagent type: catalyst
  reagent type: ligand
reaction type: C-H Activation
refractive index n/D 1.516
SMILES string NC(C)(C)C1=CC=CC=N1
Application: The Shi Auxiliary is a powerful directing group for the hydroxylation of arenes through copper-mediated C-H activation. This useful auxiliary can be removed through acid-mediated hydrolysis and has shown to be done on gram-scale.
General description: 2-(Pyridin-2-yl)isopropyl amine (PIP-amine) is a tertiary amine. A bidentate directing group, useful for the functionalization of C-H bond, has been developed from PIP-amine.
Other Notes: Copper-Mediated Hydroxylation of Arenes and Heteroarenes Directed by a Removable Bidentate Auxiliary 
Packaging: 500 mg in glass bottle
Purity 95% (GC)
Density 0.9800 g/mL at 25 °C
Refractive Index n/D 1.516
UNSPSC 12352100

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