EMCH (N-(ε-maleimidocaproic acid) hydrazide, trifluoroacetic acid salt)

ALDRICH/803677

Empirical Formula (Hill Notation): C₁₀H₁₅N₃O₃· CF₃CO₂H
Molecular Weight: 339.27
Linear Formula: C₁₀H₁₅N₃O₃· CF₃CO₂H
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-803677-50MG	50 mg	$412.00 1/EA		Add To Favorites

Properties
Descriptions
Safety Info.
Basic Data

assay	≥90%
form	powder
functional group	hydrazide
	maleimide
InChI	1S/C10H15N3O3.C2HF3O2/c11-12-8(14)4-2-1-3-7-13-9(15)5-6-10(13)16;3-2(4,5)1(6)7/h5-6H,1-4,7,11H2,(H,12,14);(H,6,7)
InChI key	DRURMGRBAVYWCL-UHFFFAOYSA-N
mol wt	339.27
Quality Level	100
reaction suitability	reagent type: cross-linking reagent
shipped in	ambient
SMILES string	O=C(C=CC1=O)N1CCCCCC(N[NH3+])=O.[O-]C(C(F)(F)F)=O
solubility	water: soluble
storage condition	desiccated
storage temp.	2-8°C

Caution:	This product is sensitive to moisture. The vial is packaged in a resealable bag with a desiccant to reduce exposure to moisture. After cold storage, equilibrate the vial to room temperature before opening to reduce condensation inside the vial. Make fresh solutions. Storage of stock solutions is not recommended. After use, return the vial to the resealable bag. Close the bag and store the product at the recommended temperature.
Features and Benefits:	• Reactive groups: maleimide and hydrazide • Reactive towards: sulfhydryl groups and carbonyl (aldehyde) groups • Mid-length (11.8Å), sulfhydryl-to-aldehyde crosslinker with simple spacer arm (noncleavable) • Maleimide group reacts with sulfhydryl groups to form stable thioether linkages • Hydrazide group conjugates to oxidized sugars of glycoproteins and carbohydrates • Use sodium meta-periodate to oxidize glycosylation (e.g., sialic acid) to reactive aldehyde groups • Use with EDC to conjugate primary amine of hydrazide group to carboxyl groups
General description:	3,3′-N-[ε-Maleimidocaproic acid] hydrazide, trifluoroacetic acid salt (EMCH) is a water-soluble, heterobifunctional, membrane permeable crosslinker. It contains a sulfhydryl reactive maleimide group and carbonyl reactive hydrazide group at each end of a 6-carbon spacer arm. Maleimides react with sulfhydryls at pH 6.5-7.5 to form stable thiol ether bonds, along with release of the maleimide leaving group. Proteins with cysteine residues not involved in disulfide bond formation are targets for maleimide reactive groups. Carbonyl groups, whilst not found naturally on proteins can be formed by ring sugar reduction to form aldehydes which react with hydrazides at pH5.5-7.5.

Symbol	GHS07
Signal word	Warning
Hazard statements	H315 - H319 - H335
Precautionary statements	P302 + P352 - P305 + P351 + P338
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥90%
Storage Temp.	2-8°C
UNSPSC	12352125

Choose a favorite list for this item:

Catalog Number	Description	Price

		$

Please choose a list :

Continue Shopping

Returns/Order support

Please fill out the form below if you want to request order support from Krackeler Scientific.