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APN-COCI

ALDRICH/807745

Synonym: 4-(cyanoethynyl)benzoyl chloride

Empirical Formula (Hill Notation): C10H4ClNO
Molecular Weight: 189.60
MDL Number: MFCD29059837
Linear Formula: C10H4ClNO
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-807745-50MG 50 mg
 $153.00
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form powder
InChI 1S/C10H4ClNO/c11-10(13)9-5-3-8(4-6-9)2-1-7-12/h3-6H
InChI key OWNJCJKKKZXTIX-UHFFFAOYSA-N
Quality Level 100 
reaction suitability reagent type: cross-linking reagent
SMILES string N#CC#CC1=CC=C(C(Cl)=O)C=C1
storage temp. 2-8°C
Application: APN-COCl is a bifunctional reagent appropriate for the introduction of APN function.
Other Notes: The coupling between an amine and APN-COCl should be performed in dry organic solvents (e.g. THF) in the presence of a base (e.g. TEA). The resulting conjugate can be readily coupled with thiol-containing biomolecules using the following protocol:

• Dissolve the protein in the appropriate buffer with pH 6.5-9.0 (e.g. PBS) at 1-10 mg/mL concentration.
• Apply the appropriate amount of the stock solution of the APN-labeled molecule (1-5 molar eq. per free cysteine residue).
• Incubate at room temperature for 2 hours.
If necessary, purify the protein conjugate using size exclusion chromatography or ultrafiltration.
Packaging: 50 mg in glass bottle
Storage Temp. 2-8°C
UNSPSC 12352101

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