SLAP HydroPyrrolopyrazine Reagent

ALDRICH/900403

Synonym: (S)-(1-((Trimethylsilyl)methyl)pyrrolidin-2-yl)methanamine

Empirical Formula (Hill Notation): C₉H₂₂N₂Si
Molecular Weight: 186.37
Linear Formula: C₉H₂₂N₂Si
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-900403-500MG	500 mg	$130.00 1/EAAdd To Favorites		Add To Favorites

density	0.8846 g/mL
form	liquid
functional group	amine
Quality Level	100
storage temp.	−20°C

Application:	Silicon amine protocol (SLAP ) reagents, in conjunction with aldehydes and ketones, form N-unprotected piperazines via photocatalytic cross-coupling with Ir[(ppy)₂dtbbpy]PF₆ (747769 ). Heteroaromatic, aromatic, and aliphatic aldehydes are well tolerated, as are structurally and stereochemically complex SLAP reagents. This product was introduced in collaboration with the Bode Research Group and provides a tin-free alternative to SnAP (tin amine protocol) reagents for piperazine synthesis.
Other Notes:	• Technology Spotlight: SLAP Reagents for Piperazine Synthesis • Silicon Amine Reagents for the Photocatalytic Synthesis of Piperazines from Aldehydes and Ketones • Lewis Acid Induced Toggle from Ir(II) to Ir(IV) Pathways in Photocatalytic Reactions: Synthesis of Thiomorpholines and Thiazepanes from Aldehydes and SLAP Reagents. • Continuous Flow Synthesis of Morpholines and Oxazepanes with Silicon Amine Protocol (SLAP) Reagents and Lewis Acid Facilitated Photoredox Catalysis
Packaging:	500 mg in amber glass bottle