3-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)propanoic acid
ALDRICH/900831
Synonym: Carboxyl diazirine alkyne; Probe building block
CAS Number: 1450754-37-6
Empirical Formula (Hill Notation): C8H10N2O2
Molecular Weight: 166.18
MDL Number: MFCD31433997
Linear Formula: C8H10N2O2
Product Type: Chemical
| availability | available only in USA |
| form | liquid |
| Quality Level | 100  |
| reaction suitability | reaction type: click chemistry |
| SMILES string | C#CCCC1(N=N1)CCC(O)=O |
| storage temp. | −20°C |
| Application: | Used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its acid linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments. |
| Other Notes: | Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling  Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein |
| Other Notes: | Technology Spotlight: Trifuctional Probe Building Blocks |
| Symbol |  GHS02 |
| Signal word | Danger |
| Hazard statements | H242 |
| Precautionary statements | P210 - P234 - P235 - P240 - P370 + P378 - P403 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | −20°C |
| UNSPSC | 12352106 |