3-(3-(But-3-yn-1-yl)-3H-diazirin-3-yl)propanoic acid

ALDRICH/900831

Synonym: Carboxyl diazirine alkyne; Probe building block

CAS Number: 1450754-37-6
Empirical Formula (Hill Notation): C₈H₁₀N₂O₂
Molecular Weight: 166.18
MDL Number: MFCD31433997
Linear Formula: C₈H₁₀N₂O₂
Product Type: Chemical

Catalog Number	PKG Qty.	Price	Quantity


45-900831-50MG	50 mg	$305.00 1/EAAdd To Favorites		Add To Favorites

availability	available only in USA
form	liquid
Quality Level	100
reaction suitability	reaction type: click chemistry
SMILES string	C#CCCC1(N=N1)CCC(O)=O
storage temp.	−20°C

Application:	Used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and carboxylic acid synthetic handle. When appended to a ligand or pharmacophore through its acid linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments.
Other Notes:	Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling Fluorescein Derivatives as Bifunctional Molecules for the Simultaneous Inhibiting and Labeling of FTO Protein
Other Notes:	Technology Spotlight: Trifuctional Probe Building Blocks