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3-Bromo-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride

ALDRICH/900859 - ≥95%

Synonym: Bromo sulfonyl fluoride TMS-alkyne; Probe building block

CAS Number: 2088829-15-4
Empirical Formula (Hill Notation): C11H12BrFO2SSi
Molecular Weight: 335.26
Linear Formula: C11H12BrFO2SSi
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-900859-50MG 50 mg
 $275.00
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assay ≥95%
form powder or crystals
Quality Level 100 
reaction suitability reaction type: click chemistry
storage temp. −20°C
Application: 3-Bromo-5-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride is used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for SuFEx -enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks  to discover the optimal probe for your chemical biology experiments.
Other Notes: Technology Spotlight: Trifunctional Probe Building Blocks 

Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis 
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95%
Storage Temp. −20°C
UNSPSC 12352200

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