2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol

ALDRICH/900863 - ≥95%

Synonym: 3-(3-Butyn-1-yl)-3H-diazirine-3-ethanol; Hydroxyl diazirine alkyne; Probe building block

CAS Number: 1450754-41-2
Empirical Formula (Hill Notation): C₇H₁₀N₂O
Molecular Weight: 138.17
MDL Number: MFCD29918290
Linear Formula: C₇H₁₀N₂O
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-900863-50MG	50 mg	$349.00 1/EAAdd To Favorites	Add To Favorites

assay	≥95%
density	1.08 g/mL
form	liquid
Quality Level	100
SMILES string	OCCC1(N=N1)CCC#C
storage temp.	−20°C

Application:

2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol is used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and hydroxyl synthetic handle. When appended to a ligand or pharmacophore through its hydroxyl linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks External link

to discover the optimal probe for your chemical biology experiments.

Other Notes:

Technology Spotlight: Trifunctional Probe Building Blocks External link

Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases External link

In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors External link

Reversible inhibitors arrest ClpP in a defined conformational state that can be revoked by ClpX association External link

Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling External link

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
Density	1.08 g/mL
Storage Temp.	−20°C
UNSPSC	12352200