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2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol

ALDRICH/900863 - ≥95%

Synonym: 3-(3-Butyn-1-yl)-3H-diazirine-3-ethanol; Hydroxyl diazirine alkyne; Probe building block

CAS Number: 1450754-41-2
Empirical Formula (Hill Notation): C7H10N2O
Molecular Weight: 138.17
MDL Number: MFCD29918290
Linear Formula: C7H10N2O
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-900863-50MG 50 mg
 $349.00
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assay ≥95%
density 1.08 g/mL
form liquid
InChI 1S/C7H10N2O/c1-2-3-4-7(5-6-10)8-9-7/h1,10H,3-6H2
InChI key NMIZSJAOOMXKDJ-UHFFFAOYSA-N
Quality Level 100 
SMILES string OCCC1(N=N1)CCC#C
storage temp. −20°C
Application: 2-(3-But-3-ynyl-3H-diazirin-3-yl)-ethanol is used for chemical probe synthesis, this trifunctional building block contains a light-activated diazirine, alkyne tag, and hydroxyl synthetic handle. When appended to a ligand or pharmacophore through its hydroxyl linker, this building block allows for UV light-induced covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks  to discover the optimal probe for your chemical biology experiments.
Other Notes:
Technology Spotlight: Trifunctional Probe Building Blocks 

Fluorescent Probes for Single-Step Detection and Proteomic Profiling of Histone Deacetylases 

In Situ Proteome Profiling and Bioimaging Applications of Small-Molecule Affinity-Based Probes Derived From DOT1L Inhibitors 

Reversible inhibitors arrest ClpP in a defined conformational state that can be revoked by ClpX association 

Design and Synthesis of Minimalist Terminal Alkyne-Containing Diazirine Photo-Crosslinkers and Their Incorporation into Kinase Inhibitors for Cell- and Tissue-Based Proteome Profiling 
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95%
Density 1.08 g/mL
Storage Temp. −20°C
UNSPSC 12352200

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