4-(Bromomethyl)-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride
ALDRICH/900864 - ≥95%
Synonym: Bromo sulfonyl fluoride TMS-alkyne; Probe building block
CAS Number: 2088828-99-1
Empirical Formula (Hill Notation): C12H14BrFO2SSi
Molecular Weight: 349.29
Linear Formula: C12H14BrFO2SSi
Product Type: Chemical
assay | ≥95% |
availability | available only in USA |
form | powder or crystals |
Quality Level | 100 |
SMILES string | O=S(C(C(C#C[Si](C)(C)C)=C |
storage temp. | −20°C |
Application: | Used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for SuFEx -enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks to discover the optimal probe for your chemical biology experiments. |
Other Notes: | • 1.Technology Spotlight: Trifunctional Probe Building Blocks • 2.Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis |
Symbol | GHS02 |
Signal word | Danger |
Hazard statements | H242 |
Precautionary statements | P210 - P234 - P235 - P240 - P370 + P378 - P403 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% |
Storage Temp. | −20°C |
UNSPSC | 12352200 |