4-(Bromomethyl)-2-((trimethylsilyl)ethynyl)benzenesulfonyl fluoride

ALDRICH/900864 - ≥95%

Synonym: Bromo sulfonyl fluoride TMS-alkyne; Probe building block

CAS Number: 2088828-99-1
Empirical Formula (Hill Notation): C₁₂H₁₄BrFO₂SSi
Molecular Weight: 349.29
Linear Formula: C₁₂H₁₄BrFO₂SSi
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-900864-50MG	50 mg	$90.50 1/EAAdd To Favorites	Add To Favorites

assay	≥95%
availability	available only in USA
form	powder or crystals
Quality Level	100
SMILES string	O=S(C(C(C#C[Si](C)(C)C)=C1)=CC=C1CBr)(F)=O
storage temp.	−20°C

Application:

Used for chemical probe synthesis, this trifunctional building block contains an aryl sulfonyl fluoride group, alkyne tag, and bromine synthetic handle. When appended to a ligand or pharmacophore through its brominated linker, this building block allows for SuFEx External link

-enabled, context-specific covalent modification of a biological target with potential for downstream applications via the alkyne tag. Use alone or in parallel with other multi-functional building blocks External link

to discover the optimal probe for your chemical biology experiments.

Other Notes:

• 1.Technology Spotlight: Trifunctional Probe Building Blocks External link

• 2.Chemoselective Preparation of Clickable Aryl Sulfonyl Fluoride Monomers: A Toolbox of Highly Functionalized Intermediates for Chemical Biology Probe Synthesis External link

Symbol	GHS02
Signal word	Danger
Hazard statements	H242
Precautionary statements	P210 - P234 - P235 - P240 - P370 + P378 - P403
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
Storage Temp.	−20°C
UNSPSC	12352200