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Tetrazine-PEG5-NHS ester

ALDRICH/900913 - ≥95%

Synonym: Tz-PEG5-NHS

CAS Number: 1682653-80-0
Empirical Formula (Hill Notation): C27H36N6O10
Molecular Weight: 604.61
MDL Number: MFCD28505547
Linear Formula: C27H36N6O10
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-900913-50MG 50 mg
 $403.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 900913-50MG.

 

assay ≥95%
form powder or crystals
functional group NHS ester
InChI 1S/C27H36N6O10/c34-23(28-19-21-1-3-22(4-2-21)27-31-29-20-30-32-27)7-9-38-11-13-40-15-17-42-18-16-41-14-12-39-10-8-26(37)43-33-24(35)5-6-25(33)36/h1-4,20H,5-19H2,(H,28,34)
InChI key DUPHIQYIPUTDJS-UHFFFAOYSA-N
Quality Level 100 
reaction suitability reaction type: click chemistry
  reagent type: linker
SMILES string O=C(NCC1=CC=C(C2=NN=CN=N2)C=C1)CCOCCOCCOCCOCCOCCC(ON3C(CCC3=O)=O)=O
storage temp. −20°C
Application: Tetrazine-PEG5-NHS ester (Tz-PEG5-NHS) can be used in click chemistry applications such as the preparation of chitosan-polyacrylamide microspheres utilizing selective tetrazine-trans-cyclooctene (Tz-TCO) ligation and the construction of copper-64 radiolabeled antibody by the click reaction.
General description: Tetrazine-PEG5-NHS ester has an N-hydroxysuccinimide (NHS) ester that can be reacted with primary amines and tetrazine, which is reactive to trans-cyclooctenes. Hydrogen substituted tetrazines demonstrate exceptionally fast kinetics, generally at least 10-fold faster compared to methyl substituted tetrazines. The aqueous solubility of this reagent is substantially enhanced by a hydrophilic polyethylene glycol (PEG) spacer arm.
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95%
Storage Temp. −20°C
UNSPSC 12352108

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