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(S,S,S)-AHPC hydrochloride

ALDRICH/901487 - ≥97%

Synonym: (2S,4S)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride; E3 Ligase ligand negative control epimer; Ligand for PROTAC® research; VH032 negative control

CAS Number: 2115897-23-7
Empirical Formula (Hill Notation): C22H30N4O3S · xHCl
Molecular Weight: 430.56 (free base basis)
Linear Formula: C22H30N4O3S · xHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-901487-10MG 10 mg
 $300.00
1/EA		 Add To Favorites
45-901487-100MG 100 mg
 $0.00
1/EA
CALL FOR PRICE		 Add To Favorites
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 901487-10MG.

 

assay ≥97%
form powder or crystals
ligand VH032
Quality Level 100 
reaction suitability reagent type: ligand
SMILES string N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@H](O)C1)=O)C(C)(C)C.Cl
storage temp. 2-8°C
Application: (S,S,S)-AHPC (HCl salt) is a ligand used as a negative control for (S,R,S)-AHPC (cat# 901490 ) in the recruitment of the von Hippel–Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology.
Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation 

Portal: Building PROTAC® Degraders for Targeted Protein Degradation 

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4 

Small-Molecule PROTACS: New Approaches to Protein Degradation 

Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase 1 

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298) 
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97%
Storage Temp. 2-8°C
UNSPSC 12352101

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