(S,R,S)-AHPC hydrochloride

ALDRICH/901490 - ≥97%

Synonym: (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride; E3 Ligase ligand; Ligand for PROTAC^® research; VH032

CAS Number: 1448189-80-7
Empirical Formula (Hill Notation): C₂₂H₃₀N₄O₃S · xHCl
Molecular Weight: 430.56 (free base basis)
MDL Number: MFCD30502992
Linear Formula: C₂₂H₃₀N₄O₃S · xHCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-901490-100MG	100 mg	$560.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 901490-100MG.

Properties
Descriptions
Safety Info.
Basic Data

assay	≥97%
form	powder or crystals
ligand	VH032
Quality Level	100
reaction suitability	reagent type: ligand
SMILES string	N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C.Cl
storage temp.	2-8°C

Application:	(S,R,S)-AHPC (HCl salt) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This (S,R,S) conformation is the active variant, and (S,S,S) is the inactive derivative (cat#901487 ) used as a negative control.
Legal Information:	PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes:	Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC^® Degraders for Targeted Protein Degradation Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities Modular PROTAC Design for the DegradationofOncogenic BCR-ABL Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4 Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥97%
Storage Temp.	2-8°C
UNSPSC	12352101

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