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(S,R,S)-AHPC hydrochloride

ALDRICH/901490 - ≥97%

Synonym: (2S,4R)-1-((S)-2-Amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride; E3 Ligase ligand; Ligand for PROTAC® research; VH032

CAS Number: 1448189-80-7
Empirical Formula (Hill Notation): C22H30N4O3S · xHCl
Molecular Weight: 430.56 (free base basis)
MDL Number: MFCD30502992
Linear Formula: C22H30N4O3S · xHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-901490-100MG 100 mg
 $560.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 901490-100MG.

 

assay ≥97%
form powder or crystals
InChI key JYRTWGCWUBURGU-MSSRUXLCSA-N
ligand VH032
Quality Level 100 
reaction suitability reagent type: ligand
SMILES string N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C.Cl
storage temp. 2-8°C
Application: (S,R,S)-AHPC (HCl salt) is a ligand used in the recruitment of the von Hippel-Lindau (VHL) protein for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This (S,R,S) conformation is the active variant, and (S,S,S) is the inactive derivative (cat#901487 ) used as a negative control.
Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation 

Portal: Building PROTAC® Degraders for Targeted Protein Degradation 

Structure-Guided Design and Optimization of Small Molecules Targeting the Protein-Protein Interaction between the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase and the Hypoxia Inducible Factor (HIF) Alpha Subunit with in Vitro Nanomolar Affinities 

Modular PROTAC Design for the DegradationofOncogenic BCR-ABL 

Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4 

Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel–Lindau (VHL) E3 Ubiquitin Ligase: Structure–Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298) 
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥97%
Storage Temp. 2-8°C
UNSPSC 12352101

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