Pomalidomide-PEG3-NH2 hydrochloride
ALDRICH/901495 - ≥95%
Synonym: 2-
Empirical Formula (Hill Notation): C21H26N4O8 · xHCl
Molecular Weight: 462.45 (free base basis)
Linear Formula: C21H26N4O8 · xHCl
Product Type: Chemical
Partial PROTACs are E3 ligase ligand-linker conjugates that simplify PROTAC synthesis. By selecting Partial PROTACs with the same terminal chemistry, several PROTACs can be synthesized in parallel from one starting target-specific ligand of the researcher′s choice.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 901495-50MG.
| assay | ≥95% |
| form | powder or crystals |
| functional group | amine |
| ligand | pomalidomide |
| Quality Level | 100  |
| reaction suitability | reactivity: carboxyl reactive |
| reagent type: ligand-linker conjugate | |
| shipped in | wet ice |
| SMILES string | O=C(C(CC1)N(C2=O)C(C3=C2C |
| storage temp. | 2-8°C |
| Application: | Protein degrader builiding block Pomalidomide-PEG3-NH2 (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology . This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Automate your CRBN-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002 ) |
| Legal Information: | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
| Other Notes: | Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC® Degraders for Targeted Protein Degradation Targeted Protein Degradation by Small Molecules  Small-Molecule PROTACS: New Approaches to Protein Degradation Targeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Purity | ≥95% |
| Storage Temp. | 2-8°C |
| UNSPSC | 12352101 |