(S,R,S)-AHPC-PEG₃-NH₂ hydrochloride

ALDRICH/901511 - ≥95%

Synonym: (2S,4R)-1-((S)-14-Amino-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride; Crosslinker–E3 Ligase ligand conjugate; Protein degrader building block for PROTAC^® research; Template for synthesis of targeted protein degrader; VH032 conjugate

CAS Number: 2097971-11-2
Empirical Formula (Hill Notation): C₃₀H₄₅N₅O₇S · xHCl
Molecular Weight: 619.77 (free base basis)
Linear Formula: C₃₀H₄₅N₅O₇S · xHCl
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-901511-50MG	50 mg	$840.00 1/EA	Add To Favorites

Partial PROTACs are E3 ligase ligand-linker conjugates that simplify PROTAC synthesis. By selecting Partial PROTACs with the same terminal chemistry, several PROTACs can be synthesized in parallel from one starting target-specific ligand of the researcher′s choice.

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
form	powder or crystals
functional group	amine
ligand	VH032
Quality Level	100
reaction suitability	reactivity: carboxyl reactive
	reagent type: ligand-linker conjugate
SMILES string	O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(COCCOCCOCCN)=O)=O.Cl
storage temp.	2-8°C

Application:	Protein degrader builiding block (S,R,S)-AHPC-PEG₃-NH₂ (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology . This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant amine, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002 )
Legal Information:	PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes:	Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC^® Degraders for Targeted Protein Degradation Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands Assessing Different E3 Ligases for Small Molecule Induced Protein Ubiquitination and Degradation Targeted Protein Degradation by Small Molecules Impact of linker length on the activity of PROTACs

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
Storage Temp.	2-8°C
UNSPSC	12352101

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