(S,R,S)-AHPC-PEG₃-Alkyne

ALDRICH/901533 - ≥95%

Synonym: (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13-trioxa-3-azahexadec-15-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide; Crosslinker–E3 Ligase ligand conjugate; Protein degrader building block for PROTAC^® research; Template for synthesis of targeted protein degrader; VH032 conjugate

CAS Number: 2374122-30-0
Empirical Formula (Hill Notation): C₃₂H₄₄N₄O₇S
Molecular Weight: 628.78
MDL Number: MFCD32173788
Linear Formula: C₃₂H₄₄N₄O₇S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-901533-50MG	50 mg	$678.00 1/EA	Add To Favorites

Partial PROTACs are E3 ligase ligand-linker conjugates that simplify PROTAC synthesis. By selecting Partial PROTACs with the same terminal chemistry, several PROTACs can be synthesized in parallel from one starting target-specific ligand of the researcher′s choice.

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Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
form	powder or crystals
functional group	alkyne
InChI key	VAUAWSOCVFFOPH-UWPQIUOOSA-N
ligand	VH032
Quality Level	100
reaction suitability	reaction type: click chemistry
	reagent type: ligand-linker conjugate
SMILES string	O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NC(CCOCCOCCOCC#C)=O)=O
storage temp.	2-8°C

Application:	Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology . This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand. Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002 )
Legal Information:	PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes:	Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC^® Degraders for Targeted Protein Degradation Targeted Protein Degradation by Small Molecules Small-Molecule PROTACS: New Approaches to Protein Degradation Targeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
Storage Temp.	2-8°C
UNSPSC	51171641

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