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(S,R,S)-AHPC-C6-CO2H hydrochloride

ALDRICH/901534

Synonym: 7-(((S)-1-((2S,4R)-4-Hydroxy-2-((4-(4-methylthiazol-5-yl)benzyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)amino)heptanoic acid; Crosslinker−E3 Ligase ligand conjugate; Protein degrader building block for PROTAC® research; Template for synthesis of targeted protein degrader; VH032 conjugate

Empirical Formula (Hill Notation): C29H42N4O5S · xHCl
Molecular Weight: 558.73 (free base basis)
Linear Formula: C29H42N4O5S · xHCl
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-901534-50MG 50 mg
 $502.00
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 901534-50MG.

 

assay ≥95%
form powder
functional group carboxylic acid
ligand VH032
Quality Level 100 
reaction suitability reactivity: amine reactive
  reagent type: ligand-linker conjugate
SMILES string O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H](C[C@@H](O)C3)N3C([C@H](C(C)(C)C)NCCCCCCC(O)=O)=O.Cl
storage temp. 2-8°C
Application: Protein degrader builiding block (S,R,S)-AHPC-C6-CO2H enables the synthesis of molecules for targeted protein degradation  and PROTAC (proteolysis-targeting chimeras) technology . This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and an alkyl-chain crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks  with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation 

Portal: Building PROTAC® Degraders for Targeted Protein Degradation 

Targeted Protein Degradation by Small Molecules 

Small-Molecule PROTACS: New Approaches to Protein Degradation 

Targeted Protein Degradation: from Chemical Biology to Drug Discovery 

Impact of linker length on the activity of PROTACs 
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95%
Storage Temp. 2-8°C
UNSPSC 12352101

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