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Lenalidomide

ALDRICH/901558 - ≥95%

Synonym: 1-Oxo-4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole; 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione; 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione; E3 Ligase ligand; Ligand for PROTAC® research

CAS Number: 191732-72-6
Empirical Formula (Hill Notation): C13H13N3O3
Molecular Weight: 259.26
MDL Number: MFCD07772307
Linear Formula: C13H13N3O3
Product Type: Chemical

Catalog Number PKG Qty. Price Quantity
45-901558-100MG 100 mg
$54.00
1/EA
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45-901558-1G 1 g
$183.00
1/EA
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45-901558-5G 5 g
$352.00
1/EA
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This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 901558-1G.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 901558-5G

 

assay ≥95%
form powder
InChI 1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
InChI key GOTYRUGSSMKFNF-UHFFFAOYSA-N
ligand lenalidomide
mp 265-268  °C
reaction suitability reagent type: ligand
SMILES string O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N
storage temp. 2-8°C
Application: Lenalidomide is a ligand demonstrated to bind the Cereblon (CRBN) protein. Lenalidomide, along with other thalidomide derivatives, are useful for constructing small molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology . Explore protein degrader building blocks , E3 ligase ligand-linker conjugates that simplify the synthesis and library generation of PROTACs.

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Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes: Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation 

Portal: Building PROTAC® Degraders for Targeted Protein Degradation 

Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs 

Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells 

The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins 
Symbol GHS08  GHS08
Signal word Warning
Hazard statements H361d - H373
Precautionary statements P201 - P308 + P313
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Flash Point(F) Not applicable
Flash Point(C) Not applicable
Purity ≥95%
mp 265-268  °C
Storage Temp. 2-8°C
UNSPSC 12352101

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