Lenalidomide

ALDRICH/901558 - ≥95%

Synonym: 1-Oxo-4-amino-2-(2,6-dioxopiperidin-3-yl)isoindole; 3-(4-Amino-1,3-dihydro-1-oxo-2H-isoindol-2-yl)-2,6-piperidinedione; 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione; E3 Ligase ligand; Ligand for PROTAC^® research

CAS Number: 191732-72-6
Empirical Formula (Hill Notation): C₁₃H₁₃N₃O₃
Molecular Weight: 259.26
MDL Number: MFCD07772307
Linear Formula: C₁₃H₁₃N₃O₃
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-901558-100MG	100 mg	$54.00 1/EA	Add To Favorites
45-901558-1G	1 g	$183.00 1/EA	Add To Favorites
45-901558-5G	5 g	$352.00 1/EA	Add To Favorites

This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 901558-1G.

Properties
Descriptions
Safety Info.
Basic Data

assay	≥95%
form	powder
InChI	1S/C13H13N3O3/c14-9-3-1-2-7-8(9)6-16(13(7)19)10-4-5-11(17)15-12(10)18/h1-3,10H,4-6,14H2,(H,15,17,18)
InChI key	GOTYRUGSSMKFNF-UHFFFAOYSA-N
ligand	lenalidomide
mp	265-268 °C
reaction suitability	reagent type: ligand
SMILES string	O=C1N(C2CCC(NC2=O)=O)CC3=C1C=CC=C3N
storage temp.	2-8°C

Application:	Lenalidomide is a ligand demonstrated to bind the Cereblon (CRBN) protein. Lenalidomide, along with other thalidomide derivatives, are useful for constructing small molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology . Explore protein degrader building blocks , E3 ligase ligand-linker conjugates that simplify the synthesis and library generation of PROTACs. .
Legal Information:	PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes:	Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC^® Degraders for Targeted Protein Degradation Structure of the human Cereblon–DDB1–lenalidomide complex reveals basis for responsiveness to thalidomide analogs Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins

Symbol	GHS08
Signal word	Warning
Hazard statements	H361d - H373
Precautionary statements	P201 - P308 + P313
RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Purity	≥95%
mp	265-268 °C
Storage Temp.	2-8°C
UNSPSC	12352101

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