Lenalidomide
ALDRICH/901558 - ≥95%
Synonym: 1-
CAS Number: 191732-72-6
Empirical Formula (Hill Notation): C13H13N3O3
Molecular Weight: 259.26
MDL Number: MFCD07772307
Linear Formula: C13H13N3O3
Product Type: Chemical
assay | ≥95% |
form | powder |
InChI | 1S/C13H13N3O3/c14-9-3-1-2 |
InChI key | GOTYRUGSSMKFNF-UHFFFAOYSA |
ligand | lenalidomide |
mp | 265-268 °C |
reaction suitability | reagent type: ligand |
SMILES string | O=C1N(C2CCC(NC2=O)=O)CC3= |
storage temp. | 2-8°C |
Application: | Lenalidomide is a ligand demonstrated to bind the Cereblon (CRBN) protein. Lenalidomide, along with other thalidomide derivatives, are useful for constructing small molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology . Explore protein degrader building blocks , E3 ligase ligand-linker conjugates that simplify the synthesis and library generation of PROTACs. . |
Legal Information: | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
Other Notes: | Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC® Degraders for Targeted Protein Degradation Structure of the human Cereblon–DDB1–lenalidomid Lenalidomide causes selective degradation of IKZF1 and IKZF3 in multiple myeloma cells The myeloma drug lenalidomide promotes the cereblon-dependent destruction of Ikaros proteins |
Symbol | GHS08 |
Signal word | Warning |
Hazard statements | H361d - H373 |
Precautionary statements | P201 - P308 + P313 |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Flash Point(F) | Not applicable |
Flash Point(C) | Not applicable |
Purity | ≥95% |
mp | 265-268 °C |
Storage Temp. | 2-8°C |
UNSPSC | 12352101 |