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Propargyl-PEG3-acid

ALDRICH/901565

CAS Number: 1347760-82-0
Empirical Formula (Hill Notation): C10H16O5
Molecular Weight: 216.23
MDL Number: MFCD22201521
Linear Formula: C10H16O5
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-901565-50MG 50 mg
 $124.00
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form liquid
functional group alkyne
  carboxylic acid
InChI key CJNSWLAJTZVSRB-UHFFFAOYSA-N
reaction suitability reagent type: linker
SMILES string C#CCOCCOCCOCCC(O)=O
storage temp. −20°C
Application: Propargyl-PEG3-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG3-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation .
Application: This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains three PEG units to help improve solubility.
Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Storage Temp. −20°C
UNSPSC 12352106

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