Propargyl-PEG2-acid
ALDRICH/901566
CAS Number: 1859379-85-3
Empirical Formula (Hill Notation): C8H12O4
Molecular Weight: 172.18
Linear Formula: C8H12O4
Product Type: Chemical
| form | liquid |
| functional group | alkyne |
| carboxylic acid | |
| reaction suitability | reaction type: click chemistry |
| reagent type: linker | |
| SMILES string | C#CCOCCOCCC(O)=O |
| storage temp. | −20°C |
| Application: | Propargyl-PEG2-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG2-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation  . |
| Application: | This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains two PEG units to help improve solubility. |
| Legal Information: | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Storage Temp. | −20°C |
| UNSPSC | 12352106 |