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Propargyl-PEG2-acid

ALDRICH/901566

CAS Number: 1859379-85-3
Empirical Formula (Hill Notation): C8H12O4
Molecular Weight: 172.18
MDL Number: MFCD29764323
Linear Formula: C8H12O4
Product Type: Chemical
Catalog Number PKG Qty. Price Quantity
45-901566-50MG 50 mg
 $237.00
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form liquid
functional group alkyne
  carboxylic acid
InChI 1S/C8H12O4/c1-2-4-11-6-7-12-5-3-8(9)10/h1H,3-7H2,(H,9,10)
InChI key NNWHATPXNWOQKD-UHFFFAOYSA-N
reaction suitability reaction type: click chemistry
  reagent type: linker
SMILES string C#CCOCCOCCC(O)=O
storage temp. −20°C
Application: Propargyl-PEG2-acid is a heterobifunctional, PEGylated crosslinker featuring a carboxylic acid at one end and propargyl group at the other for reaction with azide-containing compounds using click chemistry. The hydrophillic PEG linker facilitates solubility in biological applications. Propargyl-PEG2-acid can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation .
Application: This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains two PEG units to help improve solubility.
Legal Information: PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
RIDADR NONH for all modes of transport
WGK Germany WGK 3
Storage Temp. −20°C
UNSPSC 12352106

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