t-Boc-N-amido-PEG2-CH2CO2H
ALDRICH/901577 - ≥95%
CAS Number: 108466-89-3
Empirical Formula (Hill Notation): C11H21NO6
Molecular Weight: 263.29
MDL Number: MFCD17019374
Linear Formula: C11H21NO6
Product Type: Chemical
assay | ≥95% |
density | 1.15 g/cm3 (lit.) |
form | liquid |
functional group | amine |
Boc | |
carboxylic acid | |
InChI | 1S/C11H21NO6/c1-11(2,3)18 |
InChI key | OMBVJVWVXRNDSL-UHFFFAOYSA |
reaction suitability | reagent type: linker |
SMILES string | OC(COCCOCCNC(OC(C)(C)C)=O |
storage temp. | −20°C |
Application: | t-Boc-N-amido-PEG2-CH2CO2H is a heterobifunctional, PEGylated crosslinker featuring a Boc-protected amine at one end and a carboxyl group at the other. The hydrophillic PEG linker facilitates solubility in biological applications. t-Boc-N-amido-PEG2-CH2CO2H can be used for bioconjugation or as a building block for synthesis of small molecules, conjugates of small molecules and/or biomolecules, or other tool compounds for chemical biology and medicinal chemistry that require ligation. Examples of applications include its synthetic incorporation into antibody-drug conjugates or proteolysis-targeting chimeras (PROTAC® molecules) for targeted protein degradation . |
Application: | This is a crosslinker with a t-Boc protected amine on one end and a carboxyl group on the other end. The compound contains two PEG units to help improve solubility. |
Legal Information: | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
RIDADR | NONH for all modes of transport |
WGK Germany | WGK 3 |
Purity | ≥95% |
Density | 1.15 g/cm3 (lit.) |
Storage Temp. | −20°C |
UNSPSC | 51171641 |