Pomalidomide-PEG4-CO2H
ALDRICH/901824
Synonym: 1-
CAS Number: 2138440-81-8
Empirical Formula (Hill Notation): C24H31N3O10
Molecular Weight: 521.52
Linear Formula: C24H31N3O10
Product Type: Chemical
Partial PROTACs are E3 ligase ligand-linker conjugates that simplify PROTAC synthesis. By selecting Partial PROTACs with the same terminal chemistry, several PROTACs can be synthesized in parallel from one starting target-specific ligand of the researcher′s choice.
This picture is provided solely for illustration purposes. Optical properties of the actual product may deviate. Relevant product information is printed on labeled products and other accompanying or available information material. This image depicts SKU: 901824-50MG.
| form | solid |
| functional group | carboxylic acid |
| ligand | pomalidomide |
| reaction suitability | reactivity: amine reactive |
| reagent type: ligand-linker conjugate | |
| SMILES string | O=C(C(CC1)N(C2=O)C(C3=C2C |
| storage temp. | 2-8°C |
| Application: | Protein degrader builiding block Pomalidomide-PEG4-CO2H enables the synthesis of molecules for targeted protein degradation  and PROTAC (proteolysis-targeting chimeras) technology .This conjugate contains a Cereblon (CRBN)-recruiting ligand and a PEGylated crosslinker with pendant carboxylic acid for reactivity with an amine on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant carboxyl group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition and E3 ligase ligand.Automate your CRBN-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002 ) |
| Legal Information: | PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license |
| Other Notes: | Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC® Degraders for Targeted Protein Degradation Targeted Protein Degradation by Small Molecules  Small-Molecule PROTACS: New Approaches to Protein Degradation Targeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs Development of Highly Potent and Selective Steroidal Inhibitors and Degraders of CDK8 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | WGK 3 |
| Flash Point(F) | Not applicable |
| Flash Point(C) | Not applicable |
| Storage Temp. | 2-8°C |
| UNSPSC | 51171641 |