(S,R,S)-AHPC-PEG₅-NH₂ hydrochloride

ALDRICH/901850

Synonym: (2S,4R)-1-((S)-20-Amino-2-(tert-butyl)-4-oxo-6,9,12,15,18-pentaoxa-3-azaicosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide hydrochloride; Crosslinker−E3 ligase ligand conjugate; Protein degrader building block for PROTAC^® research; Template for synthesis of targeted protein degrader; VH032 conjugate

Empirical Formula (Hill Notation): C₃₄H₅₄ClN₅O₉S
Molecular Weight: 744.34
MDL Number: MFCD32173797
Linear Formula: C₃₄H₅₄ClN₅O₉S
Product Type: Chemical

Catalog Number	PKG Qty.	Price


45-901850-50MG	50 mg	$1030.00 1/EA	Add To Favorites

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Properties
Descriptions
Safety Info.
Basic Data

form	crystals
functional group	amine
InChI	1S/C34H53N5O9S.ClH/c1-24-30(49-23-37-24)26-7-5-25(6-8-26)20-36-32(42)28-19-27(40)21-39(28)33(43)31(34(2,3)4)38-29(41)22-48-18-17-47-16-15-46-14-13-45-12-11-44-10-9-35;/h5-8,23,27-28,31,40H,9-22,35H2,1-4H3,(H,36,42)(H,38,41);1H/t27-,28+,31-;/m1./s1
InChI key	FJDKQBVZPSNEBT-LJGPDLSOSA-N
ligand	VH032
reaction suitability	reactivity: carboxyl reactive
	reagent type: ligand-linker conjugate
SMILES string	O=C(COCCOCCOCCOCCOCCN)N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C.Cl
storage temp.	2-8°C

Application:	Protein degrader building block (SRS)-AHPC-PEG₅-NH₂ (HCl salt) enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology . This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant amine for reactivity with a carboxyl group on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target E3 ligase and PROTAC many analogs are prepared to screen for optimal target degradation.When used with other protein degrader building blocks with a pendant amine parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length composition and E3 ligase ligand. Automate your VHL-PEG based PROTACs with Synple Automated Synthesis Platform (SYNPLE-SC002 )
Legal Information:	PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license
Other Notes:	Technology Spotlight: Degrader Building Blocks for Targeted Protein Degradation Portal: Building PROTAC^® Degraders for Targeted Protein Degradation Targeted Protein Degradation by Small Molecules Small-Molecule PROTACS: New Approaches to Protein Degradation Targeted Protein Degradation: from Chemical Biology to Drug Discovery Impact of linker length on the activity of PROTACs

RIDADR	NONH for all modes of transport
WGK Germany	WGK 3
Flash Point(F)	Not applicable
Flash Point(C)	Not applicable

Storage Temp.	2-8°C
UNSPSC	12352101

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